Submitted to: American Chemical Society Abstracts
Publication Type: Abstract Only
Publication Acceptance Date: 4/15/2002
Publication Date: 8/18/2003
Citation: FINKENSTADT, V.L., HITT, H., WILLETT, J.L. CONTROLLED RELEASE USING STARCH AS A FLOATING DOSAGE MATRIX. AMERICAN CHEMICAL SOCIETY ABSTRACTS. 2003. Abstract p. 167.
Technical Abstract: Starch-based polymeric materials were tested using model drug compounds to determine the feasibility of using starch as an oral floating dosage matrix. Oral controlled release systems require increased bio-availability, predictable release rates, and site-specific delivery. Starch and model drug compounds were blended and then "puffed" on a single extruder. Model drug compounds were chosen for specific functionality. Materials were characterized for pore size, porosity, controlled release in an aqueous environment, and mechanical properties including buoyancy and overall strength.