Submitted to: Book Chapter
Publication Type: Book / chapter
Publication Acceptance Date: 2/20/2001
Publication Date: 3/1/2002
Citation: Manthey, J.A., Buslig, B.S., Baker, M.E. Flavonoids in cell function. Buslig, B.S., Manthey, J.A., editors. Kluwer Academic/Plenum Publishers, New York, NY. Flavonoids in Cell Function. 2002. p. 1-7. Interpretive Summary:
Technical Abstract: The chapters of the new book, Flavonoids in Cell Function, were introduced, and main points pertaining to the diverse biological activities of flavonoids were highlighted. The functions of flavonoids in microbe/plant interactions were discussed, followed by reviews of the use of genetic engineering and flavonoid-protein tagging to elucidate roles of flavonoids in plant development. The biological actions of flavonoids in animal cell were also discussed. The various chapters describing the antioxidant, anticancer, and antiinflammation actions of flavonoids were introduced. Several mechanisms of anticancer activities exhibited by flavonoids, including their anticarcinogenic and antitumor properties, were discussed. The roles of dietary flavonoids, including their actions as antiinflammatory and antioxidant agents, in prevention of cardiovascular disease were outlined. Compelling evidence is given for the benefits of grape juice flavonoids on cardiac function. Finally, the binding of flavonoids to proteins and to protein receptors were outlined as potential modes of action of flavonoids as phytoestrogens, or as phytoestrogenic agents.