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Title: PHOMADECALINS A-D AND PHOMAPENTENONE A: NEW BIOACTIVE METABOLITES FROM PHOMA SP. NRRL 25697, A FUNGAL COLONIST OF HYPOXYLON STROMATA

Author
item CHE, YONGSHENG - UNIV OF IA, IOWA CITY, IA
item GLOER, JAMES - UNIV OF IA, IOWA CITY, IA
item Wicklow, Donald

Submitted to: Journal of Natural Products
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 10/19/2001
Publication Date: 3/1/2002
Citation: Che, Y., Gloer, J.B., Wicklow, D.T. 2002. Phomadecalins a-d and phomapentenone a: new bioactive metabolites from phoma sp. nrrl 25697, a fungal colonist of hypoxylon stromata. Journal of Natural Products. 65(3): 399-402. 2002

Interpretive Summary: Fungi that parasitize and kill other fungi offer a potential source of new bioactive agents useful to agriculture and medicine. An isolate of Phoma, encountered as a colonist of the persistent fruit body of the wood-decay fungus Hypoxylon, was examined for its ability to produce novel bioactive metabolites. Phomadecalins A-D are reported as new fungal metabolites with activity against gram-positive bacteria.

Technical Abstract: Five new natural products, phomadecalins A-D (1-4) and phomapentenone A (5), have been obtained from cultures of Phoma sp. (NRRL 25697), a fungal colonist isolated from the stromata of Hypoxylon sp. The structures of these compounds were elucidated through a series of 1D- and 2D-NMR experiments. Compounds 1-4 display activity against gram-positive bacteria.