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ARS Home » Research » Publications at this Location » Publication #129659
Title: BIOTIN INTAKE AND EXCRETION FOR CHILDREN IN ARKANSAS

Author
item STAGGS, C - UAMS
item Bogle, Margaret
item MOCK, D - UAMS

Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: 11/1/2001
Publication Date: 4/20/2002
Citation: STAGGS, C., BOGLE, M.L., MOCK, D. BIOTIN INTAKE AND EXCRETION FOR CHILDREN IN ARKANSAS. JOURNAL OF FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY. 2002. v. 16(4). p. A614.

Interpretive Summary:

Technical Abstract: Background: Identifying children with reduced biotin status may elucidate causal relationships and risk factors. Decreased urinary biotin is an indicator of biotin deficiency. Aim: To assess the relationship between urinary biotin excretion and dietary biotin intake in children from rural and urban regions of Arkansas. Design: Twenty- four hour dietary recall data and untimed urine samples were collected for twenty-seven children. Dietary biotin intake was estimated from diet records. The HPLC/avidin-binding assay was used to measure urinary biotin and biotin catabolites. Excretion rates were normalized by creatinine. Results: Neither biotin excretion nor excretion of total biotin + catabolites correlated significantly with biotin intake. Conclusion: Based on preliminary data, biotin intake did not correlate well with urinary biotin excretion for children with normal biotin status. We speculate that other factors such as biotin absorbed after microbial release may importantly affect biotin excretion in children with normal biotin status. Alternatively, the published biotin content values based on bioassays may contain substantial errors. NIH R01 DK36823 & USDA Grant 9304550