Submitted to: Phytochemistry
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 3/5/2002
Publication Date: 6/1/2002
Interpretive Summary: The enzyme hydroxyphenylpyruvate dioxygenase is a new target site for herbicides. In our search for natural product-based pest management tools, we have discovered that this enzyme is sensitive to a variety of natural compounds. The potential benefit of this research is the development of new 'natural' pesticides.
Technical Abstract: Hydroxyphenylpyruvate dioxygenase is a relatively novel target site for triketone herbicides. The inhibitory activity of 34 natural products of various structural classes on HPPD and the mode of interaction of selected natural products were investigated.