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Title: VIRULENCE OF MAREK'S DISEASE VIRUS: ROLE OF THE 132 BP REPEATS

Author
item Silva, Robert
item LUPIANI, BLANCA - MICHIGAN STATE UNIVERSITY
item Reddy, Sanjay

Submitted to: American Veterinary Medical Association Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 7/14/2001
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Oncogenic Marek's disease virus (MDV) can be attenuated by repeatedly passing the virus in cell culture. Concomitant with attenuation is the increase in the number of copies of a 132 bp region located in TRL and IRL of the viral genome. We have mapped the RNA transcripts that originate in and around the 132 bp repeat region and will show how these transcripts are altered as MDV is attenuated. We have also deleted one open reading frame in this region and will discuss how this deletion in a vvMDV has affected pathogenesis.