Skip to main content
ARS Home » Plains Area » Grand Forks, North Dakota » Grand Forks Human Nutrition Research Center » Dietary Prevention of Obesity-related Disease Research » Research » Publications at this Location » Publication #122239
Title: DIETARY BORON PREVENTS THE ONSET OF COLLAGEN-INDUCED ARTHRITIS (CIA) IN MICE

Author
item DURICK, KELLY - UNIV OF NORTH DAKOTA
item THIELE, ALLISON - UNIV OF NORTH DAKOTA
item CLELAND, HOPE - UNIV OF NORTH DAKOTA
item GRIFFITHS, MARIE - UNIVERSITY OF UTAH
item Hunt, Curtiss
item BRADLEY, DAVID - UNIV OF NORTH DAKOTA

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 4/19/2001
Publication Date: 4/19/2001
Citation: Durick, K., Thiele, A., Cleland, H., Griffiths, M.M., Hunt, C.D., Bradley, D.S. 2001. Dietary boron prevents the onset of collagen-induced arthritis (CIA) in mice [abstract]. Presented by K. Durick at the Frank Low Research Day, University of North Dakota, Grand Forks, ND. April 19, 2001.

Interpretive Summary:

Technical Abstract: There is evidence that dietary boron, in physiological amounts, has anti- inflammatory properties. For example, dietary boron reduces adjuvant- induced arthritis in rats (Hunt et al.), a model that shares certain characteristics with human rheumatoid arthritis (RA). We describe here the effects of dietary boron in genetically susceptible (B.10T[6R]) mice immunized with heterologous type II bovine collagen (CII) to induce collagen-induced arthritis (CIA), an animal model of polyarthritis that mirrors RA in its clinical, sereological, and histological manifestations. After weaning, the mice were fed boron-deficient (~0.04 mg/kg; boron*-) or boron-adequate (2.0 mg/kg; boron*+) semi-purified diets, adequate in all vitamins and minerals, and immunized with CII at 6 and 8 wks of age. Boron*+ mice were resistant to induced arthritis: only two mice fed the boron-adequate diet developed CIA (12.5% incidence) with one of those exhibiting transitory signs only. However, boron- mice were susceptible t induced arthritis: CIA incidence in this group (56.3%) was similar to that observed when the same model was fed commercial rodent chow as reported earlier by others and us. CIA onset was slightly delayed in the boron*+ group compared to the boron*- group (49.5 9.5 and 48.0 12.5 days of onset; mean SD). At 9 weeks post-CII injection, the boron*+ mouse displayed significantly less inflammation than did boron*- mice (1.5 0.5 vs. 2.8 1.7 severity index). These findings suggest that dietary boron, in physiological amounts, is an excellent non-toxic candidate for regulating inflammation in inflammatory autoimmune diseases such as RA.