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Title: EVALUATION OF EXPERIMENTAL VACCINES FOR SUBGROUP J AVIAN LEUKOSIS VIRUS

Author
item Fadly, Aly
item Lee, Lucy
item Hunt, Henry
item GAUDRY, DANIEL - MERIAL INC GEORGIA
item BUBLOT, MICHEL - MERIAL INC GEORGIA

Submitted to: American Veterinary Medical Association Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 7/14/2001
Publication Date: 7/14/2001
Citation: FADLY, A.M., LEE, L.F., HUNT, H.D., GAUDRY, D., BUBLOT, M. EVALUATION OF EXPERIMENTAL VACCINES FOR SUBGROUP J AVIAN LEUKOSIS VIRUS. AMERICAN VETERINARY MEDICAL ASSOCIATION ABSTRACT. 2001.

Interpretive Summary:

Technical Abstract: Three experimental vaccines (two recombinant vaccines and a genetically- engineered cell line) expressing the envelope glycoprotein (gp85) of strain ADOL-Hc1 of subgroup J avian leukosis virus (ALV-J) were evaluated using commercial meat-type chickens or experimental line 0 white leghorn chickens. Using immunofluorescence, all three vaccines tested positive for expressing ALV-J gp85 in vitro; however, these vaccines failed to induce detectable neutralizing antibodies to ALV-J in vaccinated chickens. In one experiment, the incidence of ALV-J-induced viremia in vaccinated commercial chickens was lower than that in unvaccinated chickens, but only within 4-5 weeks following challenge with virus. Data suggest that one of the recombinant vaccines tested in this study may have a transient effect on the development of ALV-J-induced viremia.