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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Ruminant Diseases and Immunology Research » Research » Publications at this Location » Publication #118595
Title: COMPARATIVE EXPRESSION OF HOMING RECEPTORS ON BLOOD AND MILK CELLS OF DAIRY CATTLE

Author
item Pesch, Bruce
item Harp, James

Submitted to: Great Lakes International Imaging and Flow Cytometry Association
Publication Type: Abstract Only
Publication Acceptance Date: 10/14/2000
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Four receptors linked with leukocyte homing were compared in blood and milk samples from dairy cattle around the time of parturition. Homing accessory molecules CD11a and CD44, the peripheral homing receptor CD62L, and the mucosal homing receptor alpha4beta7, were compared in T cell subsets CD4, CD8, and gamma/delta, and in granulocytes. Milk T subsets uniformly expressed higher amounts of CD11a, CD62L, and alpha4beta7 than did blood T cells. There was no significant difference in CD44 expression between milk and blood derived T cells. The percent of granulocytes expressing CD44 was higher in blood than in milk, while alpha4beta7 expression was higher in milk than in blood. CD11a and CD62L expression was slightly lower in milk granulocytes than in blood. These findings have implications for strategies to reduce inflammatory damage caused by mastitis.