Submitted to: Organic Letters
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 3/15/2004
Publication Date: 3/18/2004
Citation: Che, Y., Gloer, J.B., Wicklow, D.T. 2004. Curvicollides A-C: new polyketide-derived lactones from a sclerotium-colonizing isolate of Podospora curvicolla (NRRL 25778). Organic Letters. 6(8):1249-1252. Interpretive Summary: There is an urgent need for new sources of antifungal agents, and fungi that kill other fungi offer a potential source of novel antifungal agents useful to agriculture and medicine. The fungus Podospora curvicolla produced antifungal agents that strongly inhibited the growth of Aspergillus flavus and Fusarium verticillioides, both toxin producers and fungal pathogens of corn kernels, Aspergillus also being an opportunistic pathogen of humans. Chemical studies revealed that some of these antifungal metabolites are new to science while others represent known compounds. Opportunistic fungal infections have become increasingly common in recent years, and new classes of environmentally friendly agricultural fungicides are also needed.
Technical Abstract: Curvicollides A and B, two new antifungal gamma-lactones, have been isolated from fermented rice cultures of Podospora curvicolla (NRRL 25778) isolated from a sclerotium of Aspergillus flavus. The structures of these compounds were elucidated by analysis of 1D and 2D NMR data.