Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: 12/10/2000
Publication Date: 3/7/2001
Citation: Spiller, G., Bruce, B., Klevay, L.M., Gallagher, S. 2000. Effects of red wine consumption on plasma antioxidant defenses in generally healthy moderate wine-drinking men [abstract]. Federation of American Societies for Experimental Biology Journal. 14:A520.
Technical Abstract: Moderate wine consumption has been linked with protective cardiovascular effects due in part because of its antioxidant activity. To evaluate the effects of regular wine consumption on endogenous antioxidant defenses, we compared a 4-week daily 10 oz consumption of a high-phenolic red wine (HI- phenolic) with 4 weeks of low-phenolic red wine (LO-phenolic), < 15 oz week, intake in a crossover design in 22 generally healthy men whose diet and lifestyle were not modified. Concentrations of erythrocyte (ErGP) and plasma glutathione perioxidase (PlGP) and superoxide dismutase (SOD) were measured at baseline (after a 4-week control period), after the first 4 week period, and after the second 4-week period. Treatment effects after 4 weeks on the HI-phenolic wine showed a significant decrease in ErGP of 21% (p<0.04) and a non-significant decrease in P1GP of 26%. SOD on average showed a non-significant decrease of 39% in both treatments. It is thought that reduction in concentrations of endogenous antioxidants induced by regular consumption of moderate amounts of red wine suggest a decreased need by the body to defined itself. Supported by an unrestricted educational grant from The Wine Institute.