Skip to main content
ARS Home » Research » Publications at this Location » Publication #110764
Title: PATHOGENESIS OF MASTITIS IN LACTATING COWS, WITH SPECIAL EMPHASIS IN THE IMMEDIATE AND EARLY EVENTS

Author
item BURVENICH, CHRISTIAN - GHENT UNIV BELGIUM
item VANGROENWEGHE, FREDERIC - GHENT UNIV BELGIUM
item Paape, Max
item MASSART-LEEN, A - GHENT UNIV BELGIUM

Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 4/5/2000
Publication Date: 9/13/2000
Citation: N/A

Interpretive Summary:

Technical Abstract: Bovine mastitis is a complex disease that has been one of the most difficult diseases to control. It is an inflammation of the udder caused by bacteria. Intramammary infections (IMI) is succeeded by local bacterial multiplication and causes diverse local and systemic responses. Because of its complexity, it should be advised to describe the pathogenesis (origin or development of a disease; Greek: pathos, disease; and genesis, originat or develop) with regard to the invading pathogen. The initial phase, the acute inflammatory reaction (AIR), observed after IMI seems to be quite uniform and short lasting (2-3 hours). Our hypothesis is that AIR is solely regulated by endogenous factors that does not depend on the invading pathogen. Therefore, this chapter will focus on: 1) the current general understanding of the different pathways that pathogens use to infect the mammary gland, 2) how these pathogens induce AIR, 3) how host factors (physiology) that control variation in the intensity of AIR, and 4) how AI can determine the final outcome and the clinical expression of mastitis (i.e. mild - moderate - severe).