Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 7/28/2000
Publication Date: N/A
Citation: Interpretive Summary:
Technical Abstract: Hydroxy fatty acids are important industrial materials derived from vegetable oils. We have been investigating the production of monohydroxy and polyhydroxy fatty acids from vegetable oils and their component fatty acids. Linoleic acid was converted to two isomeric compounds: 9,10,13(9,12,13)-trihydroxy-11(E)-octadecenoic acid by Pseudomonas aeruginosa PR3. These two isomeric compounds were isolated previously in trace amount from rice plant suffered from rice blight fungal disease. These compounds were reported to have anti-pathogenic plant fungus activity. Previously, we also reported that Clavibacter sp. ALA2 converted linoleic acid to 12,13,17-trihydroxy-9(Z)- octadecenoic acid, a new anti plant pathogenic-fungus agent. Now, we found that strain ALA2 also converted linoleic acid to four new compounds: 13,16-epoxy-7,12-dihydroxy-9(Z)- octadecenoic acid; 13,16-epoxy-12-hydroxy-9(Z)-octadecenoic acid; 12,17;13,17-diepoxy-9(Z)-octadecenoic acid and 12,17;13,17-diepoxy-9(Z)-octadecenoic acid. The isolation and structure determination of these new compounds will be discussed in details. Through biocatalysis, a large quantity of these bioactive polyhydroxy unsaturated fatty acids products can be obtained.