Submitted to: Veterinary Clinics of North America
Publication Type: Review article
Publication Acceptance Date: 4/1/2000
Publication Date: 11/1/2000
Citation: Panter, K.E., Stegelmeier, B.L. 2000. Reproductive toxicosis of food animals. Veterinary Clinics of North America. Interpretive Summary: Reproductive dysfunction has many potential causes. In this article, we discuss toxicants that have been shown to affect reproduction with emphasis on food-producing animals and fowl. The discussion is brief, and written to provide a resource for clinicians, students, and scientists by focusing on toxicant-induced reproductive dysfunction and discussing the toxicant, source, clinical effects, and livestock species known or suspected to be affected.
Technical Abstract: With the technological advances made in molecular biology, biochemistry, chemical detection, and toxicology, reproductive toxicology has made significant progress in identification of toxins and mechanisms of action. However, much of the reproductive toxicology research has been done in rodent models and may or may not be totally applicable to food-producing animals or humans. Novel molecular and biochemical probes will enable investigators to move to higher levels of sophistication in their search for mechanisms of action. The charge to protect human health, animal health and the environment from reproductive toxicants is a challenging one. An effective response will require the talents of multidisciplinary teams of scientists applying novel ideas and techniques. In this article we have attempted to provide brief information in tabular form for rapid reference with application to food producing species. While this list is undoubtedly incomplete it demonstrates the extent and complexity of diagnosing causes of reproductive dysfunction.