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ARS Home » Research » Publications at this Location » Publication #104412
Title: A NEW ADENOVIRUS SPECIES ISOLATED FROM A GOAT KID IN THE UNITED STATES

Author
item Lehmkuhl, Howard
item DEBEY, BRAD - KANSAS STATE UNIV
item Cutlip, Randall

Submitted to: American Association of Veterinary Laboratory Diagnosticians
Publication Type: Abstract Only
Publication Acceptance Date: 7/20/1999
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: A three-week old goat submitted to the Tulare Branch of the California Veterinary Diagnostic Laboratory System had adenoviral-type inclusions in villous epithelial cells of the intestine. It was one of about 50 kids with diarrhea and serous ocular and nasal discharge that had died. The kid had bronchopneumonia and epithelial necrosis in the small intestine and colon. The purpose of this study was to describe the isolation and characterization of this virus. A virus (T94-0353) isolated in ovine fetal turbinate cell cultures had cultural, morphological and physicochemical characteristics of members of the Adenoviridae family. Cross-neutralization tests comparing T94-0353 with the prototype ovine adenoviruses (OAdV), bovine adenoviruses (BAdV) and a goat adenovirus (GAdV) isolated in the United States from a goat with encephalitis showed antigenic distinction. Restriction endonuclease analyses further indicated adenovirus isolate T94-0353 produced a unique restriction pattern compared to currently recognized species of OAdV, BAdV and GAdV. We propose that strain T94-0353 represents a new goat adenovirus species and that it be designated GAdV 2. The role and significance of naturally acquired adenovirus infection in respiratory and enteric disease in goats has not been established. Adenoviruses isolated from goats, including the one in this report, all came from goats with clinical disease. The clinical importance of the T94-0353 strain of goat adenovirus remains to be determined. Isolation of adenovirus from goats with disease coupled with seroepidemiologic and pathogenicity studies will help define the role of the adenoviruses in diseases of goats.