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Identification of antifungal bisphosphocholines from medicinal Gentiana species Gentiana species including G. crassicaulis, G. macrophylla, G. dahurica, and G. straminea are used in traditional Chinese medicine (TCM) as ‘Qinjiao’ for the treatment of rheumatism, hepatitis and pain. Antifungal bisphosphocholines (irlbacholine and three new analogues, gentianalines A-C) were iden...
Circadian homeostatis of liver metabolism suppresses hepatocarcinogenesis Chronic jet lag induces spontaneous hepatocellular carcinoma (HCC) in wild-type mice following a mechanism very similar to that observed in obese humans. The process initiates with non-alcoholic fatty liver disease (NAFLD) that progresses to steatohepatitis and fibrosis before HCC detection. This pa...
Enteric virus and vibrio contamination of shellfish: intervention strategies INTRODUCTION. Molluscan shellfish include oysters, clams, mussels, and cockles, which can cause illnesses from a variety of human pathogens. Enteric viruses, like norovirus and hepatitis A virus, are generally transmitted to shellfish through fecal contamination of shellfish harvesting areas, alth...