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ARS Home » Plains Area » Houston, Texas » Children's Nutrition Research Center » Research » Publications at this Location » Publication #330716
Title: Underlying molecular and cellular mechanisms in childhood irritable bowel syndrome

Author
item CHUMPITAZI, BRUNO - Baylor College Of Medicine
item SHULMAN, ROBERT - Children'S Nutrition Research Center (CNRC)

Submitted to: Molecular and Cellular Pediatrics
Publication Type: Review Article
Publication Acceptance Date: 2/4/2016
Publication Date: 2/16/2016
Citation: Chumpitazi, B.P., Shulman, R.J. 2016. Underlying molecular and cellular mechanisms in childhood irritable bowel syndrome. Molecular and Cellular Pediatrics. 3(1):11.

Interpretive Summary:

Technical Abstract: Irritable bowel syndrome (IBS) affects a large number of children throughout the world. The symptom expression of IBS is heterogeneous, and several factors which may be interrelated within the IBS biopsychosocial model play a role. These factors include visceral hyperalgesia, intestinal permeability, gut microbiota, psychosocial distress, gut inflammation, bile acids, food intolerance, colonic bacterial fermentation, and genetics. The molecular and cellular mechanisms of these factors are being actively investigated. In this mini-review, we present updates of these mechanisms and, where possible, relate the findings to childhood IBS. Mechanistic elucidation may lead to the identification of biomarkers as well as personalized childhood IBS therapies.