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ARS Home » Northeast Area » Beltsville, Maryland (BARC) » Beltsville Agricultural Research Center » Animal Parasitic Diseases Laboratory » Research » Publications at this Location » Publication #295721
Title: Modulation of inflammatory bowel disease in a mouse model following infection with Trichinella spiralis

Author
item ZHAO, Y - Jilin University
item LIU, M - Jilin University
item WANG, X - Jilin University
item LIU, X - Jilin University
item YANG, Y - Jilin University
item ZOU, H - Jilin University
item SUN, S - Jilin University
item YU, L - Jilin University
item Rosenthal, Benjamin
item SHI, H - Massachusetts General Hospital
item BOIREAU, P - French Food And Safety Agency(AFSSA)
item WU, X - Jilin University

Submitted to: Veterinary Parasitology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 4/28/2013
Publication Date: 5/20/2013
Citation: Zhao, Y., Liu, M.Y., Wang, X.L., Liu, X.L., Yang, Y., Zou, H.B., Sun, S.M., Yu, L., Rosenthal, B.M., Shi, H.N., Boireau, P., Wu, X.P. 2013. Modulation of inflammatory bowel disease in a mouse model following infection with Trichinella spiralis. Veterinary Parasitology. 194:211-216.

Interpretive Summary: Certain parasitic infections have been observed to powerfully regulate immune responses in ways that can be either harmful or helpful. Interestingly, such infections (or products derived from such parasites) can ameliorate autoimmune syndromes, such as can occur in the colon. Here, mice prone to colitis were studied to determine the effect of infection with Trichinella spiralis, and a battery of cytokines were tracked to determine their role in enhancing or reducing the influence that such parasites might have on inflammation. Increased secretion of one cytokine, IL-10, was found to blunt the clinical benefit that could be derived. If pursued further, the biological activities of natural infection might lead to more effective management of zoonotic infection, and might also lead to better clinical management of inflammatory disease in animals and people. This would be of interest to veterinarians, epidemiologists, and clinicians.

Technical Abstract: Infection of mice with Trichinella spiralis redirects the mucosal immune system from a Th1 to a protective Th2 response with a reduction in the severity of trinitrobenzesulfonic acid-induced colonic damage. T. spiralis infection induced IL-10 production in a dose-dependent manner in oxazolone (OXZ)-induced colitis. This phenomenon may be responsible for the lack of efficacy of T. spiralis in the treatment of OXZ-induced colitis. These results indicate that if the source of increased IL-10 production is identified and addressed, T. spiralis may alter the Th2 response.