Maternal B-vitamin supplementation from preconception through weaning suppresses intestinal tumorigenesis among offspring in the Apc+/1638N mouse

Authors: CIAPPIO, ERIC - Friedman School Of Nutrition; LIU, ZHENHUA - Jean Mayer Human Nutrition Research Center On Aging At Tufts University; MASON, JOEL - Jean Mayer Human Nutrition Research Center On Aging At Tufts University; BROOKS, RYAN - Jean Mayer Human Nutrition Research Center On Aging At Tufts University; BRONSON, RODERICK - Harvard Medical School; CROTT, JIMMY - Jean Mayer Human Nutrition Research Center On Aging At Tufts University

Submitted to: Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: 4/24/2010
Publication Date: 4/24/2010
Citation: Ciappio, E.D., Liu, Z., Mason, J.B., Brooks, R.S., Bronson, R.T., Crott, J.W. 2010. Maternal B-vitamin supplementation from preconception through weaning suppresses intestinal tumorigenesis among offspring in the Apc+/1638N mouse [abstract]. Experimental Biology. Paper No. 324.

Interpretive Summary:

Technical Abstract: Folate and other B-vitamins play important roles in DNA methylation, and adequate intakes of these nutrients have been implicated in the prevention of colon cancer. Concentrations of B-vitamins in the maternal diet may impact disease susceptibility in offspring. Therefore, we investigated the effect of maternal B-vitamin intake on intestinal tumorigenesis in offspring. Our data indicate that maternal B-vitamin supplementation suppresses tumorigenesis in Apc+/1638N offspring relative to deficient and replete maternal diets and furthermore that maternal B-vitamin depletion accelerates the acquisition of invasive characteristics in tumors.