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United States Department of Agriculture

Agricultural Research Service

Related Topics

Research Project: Functional Genomics Approaches for Controlling Diseases of Poultry

Location: Animal Biosciences and Biotechnology Laboratory

Project Number: 1245-32000-097-00
Project Type: Appropriated

Start Date: Oct 13, 2011
End Date: Oct 12, 2016

Objective:
Objective 1: Develop immune reagents to detect host effector molecules controlling immune responses and determine the role of host effector molecules in disease resistance to discover biological determinants associated with disease resistance to infectious diseases of poultry. Sub-objective 1a: Develop immune reagents to detect host effector molecules controlling immune responses to NE. Sub-objective 1b: Determine the role of host effector molecular in NE disease resistance. Objective 2: Discover effective immune intervention strategies to prevent and control infectious diseases of poultry through use of nutrients as immune modulators to enhance gut health and develop strategies for their use in increasing production efficiency. Identify effector molecules of innate immunity and develop strategies for their use in reducing economic losses associated with enteric diseases of poultry. Sub-objective 2a: Use nutrients as immune modulators to enhance gut health and develop strategies for their use in increasing production efficiency. Sub-objective 2b: Identify effector molecules of innate immunity and develop strategies for their use in reducing economic losses associated with enteric diseases of poultry. Sub-objective 2c: Develop egg yolk-derived hyperimmune IgY antibodies against defined antigens of poultry enteric pathogens of economic importance and evaluate their efficacy to reduce enteric pathogens and passively transfer protective immunity in broiler chickens. Sub-objective 2d: Identify, clone and produce recombinant proteins that represent protective epitopes of enteric pathogens of economic importance to the poultry industry and develop strategies to induce pathogen-specific, broad-spectrum immunity using novel adjuvant-vectored second-generation molecular vaccines.

Approach:
Develop immune reagents to detect host effector molecules controlling immune responses. Determine the role of the host effector molecules in disease resistance. Discover biological determinants associated with disease resistance to infectious diseases of poultry.

Last Modified: 4/21/2014
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