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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » Research » Research Project #437176

Research Project: Development of a Transgenic Mouse that Expresses the Bovine Prion Polymorphism T231

Location: Virus and Prion Research

Project Number: 5030-32000-228-010-S
Project Type: Non-Assistance Cooperative Agreement

Start Date: Aug 1, 2019
End Date: Jul 31, 2024

Develop a mouse model to test the susceptibility of the bovine T231 prion polymorphism to various prion agents.

Transgene constructs will be used for microinjection into fertilized eggs and generation of the founder pups. Transgene constructs will be generated, characterized and maintained over the 2 year period to determine if transgene lines will develop a spontaneous prion disease.