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ARS Home » Plains Area » Kerrville, Texas » Knipling-Bushland U.S. Livestock Insects Research Laboratory » LAPRU » Research » Research Project #435026

Research Project: Efficacy and safety studies using a 1% doramectin product and Bm86-based anti-cattle fever tick vaccine against cattle fever ticks

Location: Livestock Arthropod Pests Research

Project Number: 3094-32000-039-55-S
Project Type: Non-Assistance Cooperative Agreement

Start Date: Jul 1, 2018
End Date: Sep 30, 2019

Objective:
Complete concentration analysis of dormectin in animal serum collected as part of efficacy and safety studies using a 1% doramectin product against cattle fever ticks.

Approach:
The amended project will consist of two studies. One will be a standard barn stall trial in which stanchioned cattle will be infested with known amounts of tick larvae at regular intervals. The animals will be treated at the label rate with 1% doramectin, Bm86-based vaccine only, or the combination of 1% doramectin and Bm86-based vaccine. A fourth group will serve as untreated controls. Regular tick infestations will occur, and the number of engorged females will be collected and counted each day. A sub-sample of the daily collected ticks will be held for fertility and fecundity measurements. The study will terminate when the level of control drops below 90% for three consecutive days. The second study will have the identical experimental design except that the cattle will be held outside in a pasture under natural conditions. Cattle will be infested at regular intervals. Tick counts will be made weekly. Up to 10 engorged females will be collected from each animal and held in the incubator for fecundity and fertility determinations. The study will terminate when efficacy reaches below 90% for three consecutive days.