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ARS Home » Plains Area » Kerrville, Texas » Knipling-Bushland U.S. Livestock Insects Research Laboratory » LAPRU » Research » Research Project #432058

Research Project: Bioinformatic Analysis of Transcriptome Data from Ticks and Biting Flies

Location: Livestock Arthropod Pests Research

Project Number: 3094-32000-036-58-N
Project Type: Non-Funded Cooperative Agreement

Start Date: Dec 15, 2016
End Date: Nov 29, 2018

Objective:
Apply bioinformatic analyses for comparative studies of veterinary pests, bovine, and human proteomes to determine protein coding transcripts that are specific to the cattle tick or horn fly, and not expressed as either human or bovine proteins.

Approach:
Utilize bioinformatics algorithms and programs to translate the transcriptome of the cattle tick and horn fly, and analyze the resulting amino acid sequences by the Blast Score Ratio program, as a platform to make comparisons between the cattle tick, horn fly, bovine, and human proteomes. The data plots obtained with the Blast Score Ratio will identify proteins in the veterinary pests of interest (cattle tick and horn fly) that have little or no similarity to human or bovine proteins.