Location: Obesity and Metabolism Research
Project Number: 2032-51530-025-101-A
Project Type: Cooperative Agreement
Start Date: Mar 22, 2024
End Date: Aug 15, 2024
Objective:
The ongoing EMILQ study has successfully collected two breast milk samples from lactating women in the first month of life in four countries involved in the MILQ study. The University of Zurich lab will analyze these samples from the EMILQ study, which is an addition to the MILQ study funded by the Bill and Melinda Gates Foundation.
Approach:
Iodine will be measured in 70 samples of human milk (breast milk iodine concentration, BMIC) collected during the first month postpartum, to add further information on iodine economy during lactation to that already determined in the main MILQ 2 study by the same team. Breast milk iodine concentration will be analyzed by multi collector inductively coupled plasma mass spectrometry (MC-ICPMS) with the use of isotope dilution analysis with 129I and Tellurium for mass bias correction. Samples will be prepared with the use of tetramethylammonium hydroxide (Tama, Kawasaki, Japan) for iodine extraction at 90°C for 180 min. Whole-milk powder standard reference material (NIST SRM1549a Whole Milk Powder; National Institute of Standards and Technology, Gaithersburg, MD) will be used as an external control.
