Research Project: Regulatory Aspects of Nutritional Metabolism

Location: Children's Nutrition Research Center

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Impact of prematurity on nutrient signaling and protein synthesis in skeletal muscle - (Review Article)
Ramos Dos Santo, A.C., Jang, K.B., Fiorotto, M.L., Davis, T.A. 2026. Impact of prematurity on nutrient signaling and protein synthesis in skeletal muscle. Annual Review of Nutrition. 46:11.1-11.25. https://doi.org/10.1146/annurev-nutr-111225-024640.

Diaphragm-specific effects of L-citrulline in mdx mice highlight its potential as adjuvant of standard therapy in Duchenne muscular dystrophy - (Peer Reviewed Journal)
Tulimiero, L., Boccanegra, B., Mantuano, P., Mele, A., De Bellis, M., Lenti, R., Sanarica, F., Cirmi, S., Conte, E., Cappellari, O., Sherrard, A.D., Green, A., Srinvasa, M., Fiorotto, M.L., De Luca, A. 2026. Diaphragm-specific effects of L-citrulline in mdx mice highlight its potential as adjuvant of standard therapy in Duchenne muscular dystrophy. British Journal of Pharmacology. https://doi.org/10.1111/bph.70437.

Weaning drives microbiome-mediated epigenetic regulation to shape immune memory in mice - (Peer Reviewed Journal)
Yang, L., Peery, R.C., Zhou, S., Chen, X., Farmer, L.M., Gutierrez, F., Fowler, S., Zhang, L., Salamat, J.M., Riggins, K., Shi, J., Shen, L. 2026. Weaning drives microbiome-mediated epigenetic regulation to shape immune memory in mice. Nature Microbiology. 11:1064-1079. https://doi.org/10.1038/s41564-026-02295-6.

Amino acid signaling in skeletal muscle is blunted by prematurity in a piglet model - (Peer Reviewed Journal)
Ramos Dos Santos, A.C., Suryawan, A., Jang, K.B., Parada, R.D., Mohammad, M.A., Fiorotto, M.L., Davis, T.A. 2026. Amino acid signaling in skeletal muscle is blunted by prematurity in a piglet model. Journal of Nutrition. 156(2). Article 101303. https://doi.org/10.1016/j.tjnut.2025.101303.

Amino acids and lean mass accretion in preterm neonates - (Review Article)
Ramos Dos Santos, A.C., Fiorotto, M.L., Davis, T.A. 2026. Amino acids and lean mass accretion in preterm neonates. Current Opinion in Clinical Nutrition and Metabolic Care. 29(1):89-97. https://doi.org/10.1097/MCO.0000000000001178.

Maximizing the Value of Preclinical and Translational Animal Research Models via Next-Generation Standardized Reference Diets: a White Paper from the Laboratory Animal Nutrition Taskforce for an Education and Research Network - (Peer Reviewed Journal)
Watts, S.A., Allison, D.B., Beitz, D.C., Booth, S.L., Coates, P.M., D'Abramo, L.R., Davis, T.A., Dilger, R.N., Erdman, J.W., Fahey, G.C., Fiorotto, M.L., Gregory, J.F., Hill, J.O., Klurfeld, D.M., Leach, S.D., Miller, P.S., Nielsen, F.H., Schalinske, K.L., Smith, D., Varga, Z.M. 2025. Maximizing the Value of Preclinical and Translational Animal Research Models via Next-Generation Standardized Reference Diets: a White Paper from the Laboratory Animal Nutrition Taskforce for an Education and Research Network. Journal of Nutrition. Article 101309. https://doi.org/10.1016/j.tjnut.2025.101309.

Whole-brain Mapping Reveals Diet-dependent Neuronal Activation and Selective Resistance to Exogenous FGF21 - (Peer Reviewed Journal)
Meng, J., Chen, X., Zhu, Y. 2025. Whole-brain Mapping Reveals Diet-dependent Neuronal Activation and Selective Resistance to Exogenous FGF21. Endocrinology. 167(1). Article bqaf176. https://doi.org/10.1210/endocr/bqaf176.

Enteral and intravenous supplementation of arginine and citrulline fail to prevent necrotizing enterocolitis in preterm neonatal pigs - (Peer Reviewed Journal)
Vonderohe, C., Mancebo, J.G., Melendez Hebib, V., Stoll, B., Didelija, I., Elefson, S., Mohammad, M., Earls, B., Guthrie, G., Burrin, D.G. 2026. Enteral and intravenous supplementation of arginine and citrulline fail to prevent necrotizing enterocolitis in preterm neonatal pigs. Journal of Parenteral and Enteral Nutrition. 50(2):252-260. https://doi.org/10.1002/jpen.70031.

Regulation of food intake by Connexin43 via adipocyte-sensory neuron electrical synapses - (Peer Reviewed Journal)
Chen, X., Fang, X., Zhou, H., Meng, J., He, Y., Straub, L.G., Lemoff, A., Crewe, C., Zhao, S., Xu, Y., Zhu, Y. 2025. Regulation of food intake by Connexin43 via adipocyte-sensory neuron electrical synapses. Molecular Metabolism. 101. Article 102247. https://doi.org/10.1016/j.molmet.2025.102247.

Restricting metabolic plasticity enhances stress adaptation through the modulation of PDH and HIFIA in TRAP1-depleted colon cancer - (Peer Reviewed Journal)
Tsai, H., Chen, M., Yun, J., Lai, L.A., Valentine, J.F., Bronner, M.P., Brentnail, T.A., Pan, S., Chen, R. 2025. Restricting metabolic plasticity enhances stress adaptation through the modulation of PDH and HIFIA in TRAP1-depleted colon cancer. Cancer Letters. 632. Article 217977. https://doi.org/10.1016/j.canlet.2025.217977.

The potential of 4-Methylumbelliferone to be repurposed for treating liver fibrosis - (Peer Reviewed Journal)
Chen, X., Li, H., Deng, Y., Meng, J., Zhao, S., Wooton-Kee, C., Gao, X., Dong, B., Guan, D., Wu, C., Scherer, P.E., Zhu, Y. 2025. The potential of 4-Methylumbelliferone to be repurposed for treating liver fibrosis. Biomedicine and Pharmacotherapy. https://doi.org/10.1016/j.biopha.2025.118427.

Multicomponent parenteral lipid emulsions do not prevent liver injury in neonatal pigs with obstructive cholestasis - (Peer Reviewed Journal)
Guthrie, G., Vonderohe, C., Hebib, V.M., Stoll, B., Burrin, D.G. 2025. Multicomponent parenteral lipid emulsions do not prevent liver injury in neonatal pigs with obstructive cholestasis. JCI Insight. 10. https://doi.org/10.1172/jci.insight.189196.

Distinct adipose progenitor cells emerging with age drive active adipogenesis - (Peer Reviewed Journal)
Wang, G., Li, G., Song, A., Zhao, Y., Yu, J., Wang, Y., Dai, W., Salas, M., Qin, H., Medrano, L., Dow, J., Li, A., Armstrong, B., Fueger, P.T., Yu, H., Zhu, Y., Shao, M., Wu, X., Jiang, L., Campisi, J., Yang, X., Wang, Q.A. 2025. Distinct adipose progenitor cells emerging with age drive active adipogenesis. Science. 388. Article eadj0430. https://doi.org/10.1126/science.adj0430.

Modeling the kinetics of interorgan arginine metabolism during bacterial sepsis in swine - (Peer Reviewed Journal)
Vonderohe, C., Burrin, D.G. 2025. Modeling the kinetics of interorgan arginine metabolism during bacterial sepsis in swine. American Journal of Physiology. 328:G309-G310. https://doi.org/10.1152/ajpgi.00375.2024.

DNA methylation profiling at base-pair resolution reveals unique epigenetic features of early-onset colorectal cancer in underrepresented populations - (Peer Reviewed Journal)
Li, J., Riggins, K., Yang, L., Chen, C., Castro, P., Alfarkh, W., Zarrin-Khameh, N., Scheurer, M.E., Creighton, C.J., Musher, B., Li, W., Shen, L. 2025. DNA methylation profiling at base-pair resolution reveals unique epigenetic features of early-onset colorectal cancer in underrepresented populations. Clinical Epigenetics. 17. Article 11. https://doi.org/10.1186/s13148-025-01817-z.

The adiponectin-PPAR axis in hepatic stellate cells regulates liver fibrosis - (Peer Reviewed Journal)
Zhao, S., Zhu, Q., Lee, W., Funcke, J., Zhang, Z., Wang, M., Lin, Q., Field, B., Sun, X., Li, G., Ekane, M., Onodera, T., Li, N., Zhu, Y., Kusminski, C.M., Hinds, T.D., Scherer, P.E. 2025. The adiponectin-PPAR axis in hepatic stellate cells regulates liver fibrosis. Cell Reports. 44. Article 115165. https://doi.org/10.1016/j.celrep.2024.115165.

Sex differences in response to diet enriched with glutathione precursors in the aging heart - (Peer Reviewed Journal)
Angelini, A., Garcia Marquez, G., Malovannaya, A., Fiorotto, M.L., Saltzman, A., Jain, A., Trial, J., Taffet, G.E., Cieslik, K.A. 2024. Sex differences in response to diet enriched with glutathione precursors in the aging heart. Gerontological Society of America. 80(2). Article glae258. https://doi.org/10.1093/gerona/glae258.

The DNA methylome of pediatric brain tumors appears shaped by structural variation and predicts survival - (Peer Reviewed Journal)
Chen, F., Zhang, Y., Shen, L., Creighton, C.J. 2024. The DNA methylome of pediatric brain tumors appears shaped by structural variation and predicts survival. Nature Communications. 15. Article 6775. https://doi.org/10.1038/s41467-024-51276-y.

Hyaluronan mediates cold-induced adipose tissue beiging - (Peer Reviewed Journal)
Chen, X., Wang, Y., Li, H., Deng, Y., Giang, C., Song, A., Liu, Y., Wang, Q.A., Zhu, Y. 2024. Hyaluronan mediates cold-induced adipose tissue beiging. Cells. 13(15). Article 1233. https://doi.org/10.3390/cells13151233.

Nutritional importance of animal-sourced foods in a healthy diet - (Peer Reviewed Journal)
Sheffield, S., Fiorotto, M.L., Davis, T.A. 2024. Nutritional importance of animal-sourced foods in a healthy diet. Frontiers in Nutrition. 11. Article 1424912. https://doi.org/10.3389/fnut.2024.1424912.