Research Project: Validate Causative Mutations in Agriculturally-Important Vertebrates

Location: Plant Genetics Research

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Effects of fluorescence-activated cell sorting on boar sperm and in vitro embryo development - (Peer Reviewed Journal)

Strain-specific responses of avian influenza virus to disruption of solute carrier family 35 member A1 (SLC35A1) in chicken cells - (Peer Reviewed Journal)

The critical functions of FGF2, LIF, and IGF1 in the improvement of in vitro embryo production - (Review Article)
Mangiavacchi, P.M., Lee, K., Redel, B.K. 2026. The critical functions of FGF2, LIF, and IGF1 in the improvement of in vitro embryo production. Biomolecules. 16(4). https://doi.org/10.3390/biom16040487.

Impact of gene duplication of B4GALNT2 in pigs for xenotransplantation- technical & practical - (Peer Reviewed Journal)
Lucas, C.G., Whitworth, K.M., Samuel, M.S., Redel, B.K., Prather, R.S., Wells, K.D. 2026. Impact of gene duplication of B4GALNT2 in pigs for xenotransplantation- technical & practical. Xenotransplantation. 33(1). https://doi.org/10.1111/xen.70115.

Highly efficient gene editing via targeted Cas9 insertion into chicken housekeeping gene - (Peer Reviewed Journal)
Jung, K., Klein, R., Mony, S., Chen, P.R., Lee, K., Lee, H. 2026. Highly efficient gene editing via targeted Cas9 insertion into chicken housekeeping gene. Poultry Science. 105(4). https://doi.org/10.1016/j.psj.2026.106585.

Enhancing the specificity of gene editing outcomes by using Cas9 variants in porcine embryos - (Peer Reviewed Journal)
Kim, J., Yoon, J., Chen, J., Lee, J., Lee, H., Whitworth, K., Redel, B.K., Prather, R.S., Lee, K. 2026. Enhancing the specificity of gene editing outcomes by using Cas9 variants in porcine embryos. Journal of Animal Science. 104. https://doi.org/10.1093/jas/skag030.

Exploring the relationship between Lone Star Virus and Synaptogyrin-2 using novel viral and host models of infection - (Peer Reviewed Journal)
Eaton, C.W., Walker, L.R., Vu, H.L., Loy, D.J., Ciobanu, D.C. 2026. Exploring the relationship between Lone Star Virus and Synaptogyrin-2 using novel viral and host models of infection. Vector-Borne and Zoonotic Diseases. 26(6). https://doi.org/10.1177/15303667261420983.

Capacitation-induced zinc ion flux and sperm plasma membrane remodeling predict porcine in vitro fertilization cleavage success - (Peer Reviewed Journal)
Rodriguez, I., Keller, A., Jennett, L., Johnson, M., Shofner, I., Mohmood, M., Redel, B.K., Kerns, K. 2026. Capacitation-induced zinc ion flux and sperm plasma membrane remodeling predict porcine in vitro fertilization cleavage success. Molecular Reproduction and Development. 93(1). https://doi.org/10.1002/mrd.70085.

Plesiomonas shigelloides as an emerging pathogen in catfish aquaculture: a case from a South Texas commercial farm - (Peer Reviewed Journal)
Mohammed, H.H., Elbanna, N.I., Erdogan, O., Aarattuthodi, S., Tekedar, H.C., Abdelhamed, H., Diaz-Delgado, J. 2026. Plesiomonas shigelloides as an emerging pathogen in catfish aquaculture: a case from a South Texas commercial farm. Microorganisms. 14(1). https://doi.org/10.3390/microorganisms14010144.

Transcriptional profiling of cumulus cells from FLI-matured porcine oocytes identifies junctional genes as key components in oocyte maturation - (Peer Reviewed Journal)
Green, C.L., Jaworski, A., Mangiavacchi, P.M., Spate, L., Walker, L.R., Prather, R.S., Lee, K., Redel, B.K. 2026. Transcriptional profiling of cumulus cells from FLI-matured porcine oocytes identifies junctional genes as key components in oocyte maturation. Molecular Reproduction and Development. 93(1). https://doi.org/10.1002/mrd.70080Digital Object Identifier (DOI).

Transcriptional profiling reveals upregulation of p53 signaling in porcine embryos produced in vitro - (Peer Reviewed Journal)
Noland, R.S., Redel, B.K., Lamartina, M.G., Prather, R.S., Chen, P.R. 2025. Transcriptional profiling reveals upregulation of p53 signaling in porcine embryos produced in vitro. Biology of Reproduction. 113(4): 777-786. https://doi.org/10.1093/biolre/ioaf113.

Expression of tripartite motif family-like protein 1 and 2 in early conceptus development and placentation in the pig - (Peer Reviewed Journal)
Eitel, E.K., Sponchiado, M., Sullivan, R.M., Lucas, C.G., Redel, B.K., Chen, P.R., Wells, K.D., Prather, R.S., Warren, W.C., Geisert, R.D. 2025. Expression of tripartite motif family-like protein 1 and 2 in early conceptus development and placentation in the pig. Journal of Reproduction and Fertility. 6(2). https://doi.org/10.1530/RAF-24-0107.

Investigation of the pathobiology of Edwardsiella piscicida – septicemia in largemouth bass - (Peer Reviewed Journal)
Ramena, G., Aarattuthodi, S., Sriramoju, G., Ramena, Y. 2025. Investigation of the pathobiology of Edwardsiella piscicida – septicemia in largemouth bass. Pathogens. https://doi.org/10.3390/pathogens14040334.

Cryopreservation of biological materials: applications and economic perspectives - (Review Article)
Aarattuthodi, S., Kang, D.S., Gupta, S., Chen, P.R., Redel, B.K., Matuha, M., Mohammed, H., Sinha, A. 2025. Cryopreservation of biological materials: applications and economic perspectives. In Vitro Cellular and Developmental Biology - Animal. https://doi.org/10.1007/s11626-025-01027-0.

Mitochondrial dysfunction is a hallmark of woody breast myopathy in broiler chickens - (Peer Reviewed Journal)
Greene, E.S., Chen, P.R., Walk, C., Bedford, M., Dridi, S. 2025. Mitochondrial dysfunction is a hallmark of woody breast myopathy in broiler chickens. Frontiers in Physiology. https://doi.org/10.3389/fphys.2025.1543788.

Response to cook et al. re: novel off-targeting events identified after genome wide analysis of CRISPR-Cas edited pig - (Other)
Redel, B.K., Lee, K. 2025. Response to cook et al. re: novel off-targeting events identified after genome wide analysis of CRISPR-Cas edited pig. The CRISPR Journal. 8(2): 77-78. https://doi.org/10.1089/crispr.2025.0003.

Up-regulation of Melanophilin (MLPH) gene during avian adipogenesis and decreased fat pad weights with adipocyte hypotrophy in MLPH knockout quail - (Peer Reviewed Journal)
Kim, D., Lee, J., Suh, Y., Chen, P.R., Lee, K. 2025. Up-regulation of Melanophilin (MLPH) gene during avian adipogenesis and decreased fat pad weights with adipocyte hypotrophy in MLPH knockout quail. Poultry Science. https://doi.org/10.1016/j.psj.2024.104720.

Effect of carryover biomass of channel catfish on production and profitability in intensively aerated multiple-batch system - (Peer Reviewed Journal)
Kumar, G., Hegde, S., Aarattuthodi, S., Bosworth, B.G., Sun, L., Steensma, N. 2025. Effect of carryover biomass of channel catfish on production and profitability in intensively aerated multiple-batch system. Journal of the World Aquaculture Society. https://doi.org/10.1111/jwas.13123.

Gentamicin has no significant adverse effect on porcine embryo development in vitro - (Peer Reviewed Journal)
Noland, R.S., Redel, B.K., Lamartina, M.G., Chen, P.R., Prather, R.S. 2024. Gentamicin has no significant adverse effect on porcine embryo development in vitro. Molecular Reproduction and Development. https://doi.org/10.1002/mrd.70008.

Efficacy determination of a disinfectant against channel catfish virus by in vitro and in vivo methods - (Peer Reviewed Journal)
Aarattuthodi, S., Bosworth, B.G., Kumar, G., Nalamalapu, A. 2024. Efficacy determination of a disinfectant against channel catfish virus by in vitro and in vivo methods. In Vitro Cellular and Developmental Biology - Animal. https://doi.org/10.1007/s11626-024-01003-0.

Research note: Increased lipid accumulation within broiler preadipocytes during differentiation in vitro at atmospheric oxygen tension - (Peer Reviewed Journal)
Cruvinel, J.M., Greene, E.S., Read, R.W., Lee, K., Dridi, S., Chen, P.R. 2024. Research note: Increased lipid accumulation within broiler preadipocytes during differentiation in vitro at atmospheric oxygen tension. Poultry Science. https://doi.org/10.1016/j.psj.2024.104531.

Fetal bone engraftment reconstitutes the immune system in pigs with severe combined immunodeficiency - (Peer Reviewed Journal)
Monarch, K., Yoon, J., Uh, K., Reese, E., Canaveral Restrepo, D., De Carvalho Madrid, D., Touchard, L., Spate, L.D., Samuel, M.S., Driver, J.P., Lim, J., Schlink, S., Whitworth, K.M., Wells, K.D., Prather, R.S., Chen, P.R., Lee, K. 2024. Fetal bone engraftment reconstitutes the immune system in pigs with severe combined immunodeficiency. Lab Animal. 53:276-286. https://doi.org/10.1038/s41684-024-01439-7.

The role of gene editing, organoids, and in vitro phenotyping in sustainable animal production - (Review Article)
Redel, B.K., Jeon, E., Green, C.C., Prather, R.S. 2024. The role of gene editing, organoids, and in vitro phenotyping in sustainable animal production. Reproduction, Fertility and Development. https://doi.org/10.1071/RD24135.

Accelerating genomic improvement in pigs by using reproductive biotechnologies - (Book / Chapter)
Redel, B.K., Chen, P.R., Telugu, B., Lucas, C., Lee, K., Whitworth, K.M., Prather, R.S. 2025. Accelerating genomic improvement in pigs by using reproductive biotechnologies. In: Ross, J.W., editor. Advances in Pig Breeding and Reproduction. London, UK: Burleigh Dodds Science Publishing. p.231-262. https://doi.org/10.19103/AS.2024.0137.16.

Impaired skeletal development by disruption of presenilin-1 in pigs and generation of novel pig models for Alzheimer’s disease - (Peer Reviewed Journal)
Uh, K., Monarch, K., Reese, E.D., Rodriguez, K., Yoon, J.D., Spate, L.D., Samuel, M.S., Koh, S., Chen, P.R., Jarome, T., Allen, T., Prather, R.S., Lee, K. 2024. Impaired skeletal development by disruption of presenilin-1 in pigs and generation of novel pig models for Alzheimer’s disease. Journal of Alzheimer's Disease. 101(2):445-461. https://doi.org/10.3233/JAD-231297.

Economic contribution of U.S. aquaculture farms - (Peer Reviewed Journal)
Kumar, G., Hegde, S., Van Senten, J., Engle, C., Boldt, N., Parker, M., Quagrainie, K., Posadas, B., Asche, F., Dey, M., Aarattuthodi, S., Roy, L., Grice, R., Fong, Q., Schwarz, M. 2024. Economic contribution of U.S. aquaculture farms. Journal of the World Aquaculture Society. 55(6). https://doi.org/10.1111/jwas.13091.

Novel off-targeting events identified after genome wide analysis of CRISPR-Cas edited pigs - (Peer Reviewed Journal)
Redel, B.K., Yoon, J., Reese, E., An, H., Uh, K., Chen, P.R., Prather, R.S., Lee, K. 2024. Novel off-targeting events identified after genome wide analysis of CRISPR-Cas edited pigs. The CRISPR Journal. 7(3): 141 - 149. https://doi.org/10.1089/crispr.2024.0012.

Oocyte recovery after overnight ovary transport provides an alternative source of cumulus oocyte complexes that are competent to produce live piglets - (Peer Reviewed Journal)
Spate, L.D., Yin, J., Sammel, L., Prather, R.S., Redel, B.K. 2023. Oocyte recovery after overnight ovary transport provides an alternative source of cumulus oocyte complexes that are competent to produce live piglets. Reproduction in Domestic Animals. 00:1-3. https://doi.org/10.1111/rda.14491.

Porcine-specific expression of the three functional CYP19 paralogs in early conceptus, placenta, and gonads - (Peer Reviewed Journal)
Lucas, C.G., Sullivan, R.M., Pfeiffer, C.A., Chen, P.R., Kim, J., Sponchiado, M.S., Conley, A.J., Prather, R.S., Wells, K.D., Geisert, R.D. 2023. Porcine-specific expression of the three functional CYP19 paralogs in early conceptus, placenta, and gonads. Reproduction. 166(4):263-269. https://doi.org/10.1530/REP-23-0189.