Research Project: Virulence Mechanisms, Microbiome Changes and Control Strategies for Priority Bacterial Infections in Swine

Location: Virus and Prion Research

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Development of vertical transmission model for Bordetella bronchiseptica in pigs - (Peer Reviewed Journal)
Hau, S.J., Devries, A.C., Arruda, B.L., Nielsen, D.W., Payne, B. 2026. Development of vertical transmission model for Bordetella bronchiseptica in pigs. Veterinary Microbiology. https://doi.org/10.1016/j.vetmic.2026.110953.

Comparative analysis of the diversity within the B. bronchiseptica fimX locus - (Peer Reviewed Journal)
Nicholson, T.L., Shore, S. 2026. Comparative analysis of the diversity within the B. bronchiseptica fimX locus. PLOS ONE. https://doi.org/10.1371/journal.pone.0342754.

The Streptococcus suis ble gene does not encode a functional bleomycin resistance protein - (Peer Reviewed Journal)
Belinfante, A., Kolar, J., Shore, S., Nicholson, T.L. 2025. The Streptococcus suis ble gene does not encode a functional bleomycin resistance protein. Veterinary Microbiology. https://doi.org/10.1016/j.vetmic.2025.110769.

Identification of candidate vaccine antigens using 2-D gel electrophoresis and immunoproteomics for cross protection against Glaesserella parasuis - (Peer Reviewed Journal)
Hau, S.J., Eberle, K.C., Nally, J.E., Nielsen, D.W., Lippolis, J.D., Brockmeier, S. 2025. Identification of candidate vaccine antigens using 2-D gel electrophoresis and immunoproteomics for cross protection against Glaesserella parasuis. Veterinary Microbiology. 307. Article 110594. https://doi.org/10.1016/j.vetmic.2025.110594.

Genetic diversity of Bordetella bronchispetica isolates obtained from primates - (Peer Reviewed Journal)
Nicholson, T.L., Shore, S., Wang, Y., Zimmerman, L., Merkel, T.J. 2025. Genetic diversity of Bordetella bronchispetica isolates obtained from primates. Frontiers in Microbiology. 16. https://doi.org/10.3389/fmicb.2025.1571660.

Chapter 52. Bordetellosis - (Book / Chapter)

Chapter 60. Staphylococcosis - (Book / Chapter)

Protection induced in pigs previously infected by the non-virulent strain 1330 of Streptococcus suis serotype 2 is not due to the secretion of the bacteriocin suicin - (Peer Reviewed Journal)
Hau, S.J., Fittipaldi, N., Payen, S., Grenier, D.W., Nielsen, D.W., Brockmeier, S., Gottschalk, M. 2025. Protection induced in pigs previously infected by the non-virulent strain 1330 of Streptococcus suis serotype 2 is not due to the secretion of the bacteriocin suicin. PLOS ONE. 20(5). Article e0323370. https://doi.org/10.1371/journal.pone.0323370.

Transcriptional profile of Glaesserella parasuis in swine serosal and joint fluids - (Peer Reviewed Journal)
Nielsen, D.W., Sarlo Davila, K.M., Brockmeier, S., Hau, S.J. 2025. Transcriptional profile of Glaesserella parasuis in swine serosal and joint fluids. Frontiers in Veterinary Science. 12. Article 1452973. https://doi.org/10.3389/fvets.2025.1452973.

Capsular immunity is necessary for protection against some but not all strains of Glaesserella parasuis - (Peer Reviewed Journal)
Hau, S.J., Luan, S., Weinert, L.A., Langford, P.R., Rycroft, A., Wren, B.W., Maskell, D.J., Tucker, A.W., Brockmeier, S. 2025. Capsular immunity is necessary for protection against some but not all strains of Glaesserella parasuis. Veterinary Microbiology. https://doi.org/10.1016/j.vetmic.2025.110509.

Streptococcus suivaginalis sp. nov., Streptococcus iners sp. nov. and Streptococcus iners subsp. hyiners subsp. nov. isolated from pigs - (Peer Reviewed Journal)
Nicholson, T.L., Stuart, K.L., Bayles, D.O. 2025. Streptococcus suivaginalis sp. nov., Streptococcus iners sp. nov. and Streptococcus iners subsp. hyiners subsp. nov. isolated from pigs. International Journal of Systematic and Evolutionary Microbiology. 75(1). https://doi.org/10.1099/ijsem.0.006631.

Comparative analysis of antimicrobial resistance and genetic diversity of Bordetella bronchiseptica isolates obtained from swine within the United States - (Peer Reviewed Journal)
Nicholson, T.L., Shore, S. 2024. Comparative analysis of antimicrobial resistance and genetic diversity of Bordetella bronchiseptica isolates obtained from swine within the United States. Frontiers in Microbiology. 15. Article 1501373. https://doi.org/10.3389/fmicb.2024.1501373.

Detection of immunogenic proteins of glaesserella parasuis using serum from protected animals - (Abstract Only)

Shifts in the swine nasal microbiota following Bordetella bronchiseptica challenge in a longitudinal study - (Peer Reviewed Journal)
Nielsen, D.W., Hau, S.J., Mou, K.T., Alt, D.P., Brockmeier, S.L. 2023. Shifts in the swine nasal microbiota following Bordetella bronchiseptica challenge in a longitudinal study. Frontiers in Microbiology. 14. Article 1260465. https://doi.org/10.3389/fmicb.2023.1260465.

Population structure and genetic diversity of streptococcus suis isolates obtained from the United States - (Peer Reviewed Journal)
Nicholson, T.L., Kalalah, A.A., Eppinger, M. 2023. Population Structure and Genetic Diversity of Streptococcus suis Isolates Obtained from the United States. Frontiers in Immunology. https://doi.org/10.3389/fmicb.2023.1250265.

Prior infection with Bordetella bronchiseptica enhanced colonization but not disease with Streptococcus suis - (Peer Reviewed Journal)
Hau, S.J., Nielsen, D.W., Brockmeier, S.L. 2023. Prior infection with Bordetella bronchiseptica enhanced colonization but not disease with Streptococcus suis. Veterinary Microbiology. 284:109841. https://doi.org/10.1016/j.vetmic.2023.109841.

Comparative Virulence and Antimicrobial Resistance Distribution of Streptococcus suis Isolates obtained from the United States - (Abstract Only)

Coinfection with Bordetella bronchiseptica does not enhance disease with Streptococcus suis - (Abstract Only)

Resilience of swine nasal microbiota to influenza A virus challenge in a longitudinal study - (Peer Reviewed Journal)
Hau, S.J., Nielsen, D.W., Mou, K.T., Alt, D.P., Kellner, S., Brockmeier, S. 2023. Resilience of swine nasal microbiota to influenza A virus challenge in a longitudinal study. BMC Veterinary Research. 54:Article 38. https://doi.org/10.1186/s13567-023-01167-9.

The contribution of BvgR, RisA, and RisS to global gene regulation, intracellular cyclic-di-GMP levels, motility, and biofilm formation in bordetella bronchiseptica - (Peer Reviewed Journal)
Nicholson, T.L., Waack, U., Fleming, D.S., Chen, Q., Miller, L.C., Merkel, T.J., Stibitz, S. 2024. The contribution of BvgR, RisA, and RisS to global gene regulation, intracellular cyclic-di-GMP levels, motility, and biofilm formation in bordetella bronchiseptica . Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2024.1305097.

Comparative virulence and antimicrobial resistance distribution of streptococcus suis isolates obtained from the United States - (Peer Reviewed Journal)
Nicholson, T.L., Bayles, D.O. 2022. Comparative virulence and antimicrobial resistance distribution of streptococcus suis isolates obtained from the United States. Frontiers in Microbiology. 13. https://doi.org/10.3389/fmicb.2022.1043529.

Rapid application of long-acting ceftiofur can prevent death losses associated with Streptococcus equi subspecies zooepidemicus in pigs - (Peer Reviewed Journal)
Hau, S.J., Buckley, A.C., Brockmeier, S. 2022. Rapid application of long-acting ceftiofur can prevent death losses associated with Streptococcus equi subspecies zooepidemicus in pigs. Swine Health and Production. 30(5):292-297. https://doi.org/10.54846/jshap/1298.

Bacterin vaccination provides insufficient protection against Streptococcus equi subspecies zooepidemicus infection in pigs - (Peer Reviewed Journal)
Hau, S.J., Devries, A.C., Brockmeier, S. 2022. Bacterin vaccination provides insufficient protection against Streptococcus equi subspecies zooepidemicus infection in pigs. Frontiers in Veterinary Science. 9. Article 827082. https://doi.org/10.3389/fvets.2022.827082.

Prevention and control of Streptococcus equi subspecies zooepidemicus infection in pigs - (Proceedings)
Hau, S.J., Devries, A.C., Brockmeier, S. 2022. Prevention and control of Streptococcus equi subspecies zooepidemicus infection in pigs. American Association of Swine Veterinarians Annual Meeting. Pg.51-52. https://doi.org/10.54846/am2022/14.