Project Number: 3022-32000-020-000-D
Project Type: In-House Appropriated
Start Date: Apr 1, 2021
End Date: Mar 31, 2026
Objective 1 (from Project No. 3020-32000-014-00D under review). Identify factors associated with Flavivirus infections, pathogenesis, and maintenance in vectors and animal hosts to inform prevention and mitigation strategies. - Identify factors associated with JEV maintenance in relevant insect vectors. - Characterize susceptibility, pathogenesis, and clinical disease of JEV in swine. - Characterize vector-host interactions associated with JEV transmission. Component 1, Problem Statement 1A Objective 2. Identify and develop JEV control measures in swine. - Develop detection measures fit for JEV surveillance in swine. - Develop JEV vaccines for swine that will prevent virus amplification. - Develop control measures to protect swine from JEV-infected Culex mosquitoes. Component 1: Problem Statement 1A
Japanese encephalitis virus (JEV) is the most important cause of human viral encephalitis in Asia. JEV is a mosquito-borne flavivirus, and belongs to the same genus as Dengue, Zika virus, yellow fever, and West Nile viruses. Although only 0.1-2.5% of JEV infections in humans result in symptoms, the mortality rate of symptomatic cases is high (20–30%), and 30–50% of survivors experience significant neurological and psychiatric sequelae. There are no licensed anti-JEV drugs, but safe and effective human vaccines are available. The research addresses the following research components in the 2022-2027 Animal Health National Program (NP 103) Action Plan: 1) Component 1: Biodefense, Problem Statement 1A, Control and eradicate foreign animal diseases. The research addresses ARS Strategic Plan Goal 4.3 and the following Performance Measure: Provide scientific information to protect animals, humans, and property from the negative effects of pests, and infectious diseases, and develop and transfer tools to the agricultural community, commercial partners, and government agencies to control or eradicate domestic and exotic diseases and pests that affect animal and human health.