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ARS Home » Southeast Area » Fayetteville, Arkansas » Poultry Production and Product Safety Research » Research » Research Project #438577

Research Project: Development of Vaccines to Control Campylobacter, Salmonella, Clostridium Perfringens, and Avian Pathogenic E. coli in Poultry

Location: Poultry Production and Product Safety Research

Project Number: 6022-31230-001-19-S
Project Type: Non-Assistance Cooperative Agreement

Start Date: Aug 1, 2020
End Date: Dec 31, 2021

Objective:
1. To develop an efficacious vaccine against multiple serotypes of Salmonella to control Salmonella colonization and shedding in chickens. 2. To develop an efficacious vaccine against multiple strains of Campylobacter to control Campylobacter colonization and shedding in chickens. 3. To develop an efficacious vaccine against multiple strains of C. perfringens to control C. perfringens colonization and shedding in chickens. 4. To develop an efficacious vaccine against multiple strains of APEC to control APEC colonization and shedding in chickens. 5. To develop an efficacious cocktail vaccine against Campylobacter, Salmonella, C. perfringens, and APEC to control their colonization and shedding in chickens.

Approach:
Bacterial cultures for irradiation will be prepared, the bacterial samples will be exposed to electron beam irradiation. The irradiated samples will then be subjected to in vitro and in vivo assays to confirm the inactivation of the irradiated pathogens and tested for efficacy as vaccines for chickens.