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ARS Home » Southeast Area » Oxford, Mississippi » Natural Products Utilization Research » Research » Research Project #438514

Research Project: Biobased Pesticide Discovery and Product Optimization and Enhancement from Medicinal and Aromatic Crops

Location: Natural Products Utilization Research

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Essential oil composition of Pinus heldreichii Christ., P. peuce Griseb., and P. mugo Turra as a function of hydrodistillation time and evaluation of its antimicrobial activity Reprint Icon - (Peer Reviewed Journal)
Semerdjieva, I.B., Radoukova, T., Cantrell, C.L., Astatkie, T., Kacanlova, M., Borisova, D., Zheljazkov, V.D. 2022. Essential oil composition of Pinus heldreichii Christ., P. peuce Griseb., and P. mugo Turra as a function of hydrodistillation time and evaluation of its antimicrobial activity. Industrial Crops and Products. 187(2022)115484. https://doi.org/10.1016/j.indcrop.2022.115484.

Chemical authentication and speciation of Salvia botanicals: an investigation utilizing GC/Q-ToF and chemometrics Reprint Icon - (Peer Reviewed Journal)
Lee, J., Wang, M., Jianping, Z., Avula, B., Chittiboyinaa, A.G., Khan, I.A. 2022. Chemical authentication and speciation of Salvia botanicals: an investigation utilizing GC/Q-ToF and chemometrics. Foods. https://doi.org/10.3390/foods11142132.

Evaluation of the phytotoxic and antifungal activity of C17-sesquiterpenoids as potential biopesticides Reprint Icon - (Peer Reviewed Journal)
Cárdenas, D.M., Bajsa Hirschel, J.N., Cantrell, C.L., Rial, C., Varela, R.M., Molinillo, J.G., Macías, F.A. 2022. Evaluation of the phytotoxic and antifungal activity of C17-sesquiterpenoids as potential biopesticides. Pest Management Science. https://doi.org/10.1002/ps.7042.

Chemometric analysis and chemical characterization for the botanical identification of Glycyrrhiza species (G. glabra, G. uralensis, G. inflata, G. echinata and G. lepidota) using liquid chromatography-quadrupole time of flig Reprint Icon - (Peer Reviewed Journal)
Avula, B., Bae, J., Chittiboyina, A.G., Wang, Y., Wang, M., Zhao, J., Zulfiqar, A., Li, J., Wu, C., Khan, I.A. 2022. Chemometric analysis and chemical characterization for the botanical identification of Glycyrrhiza species (G. glabra, G. uralensis, G. inflata, G. echinata and G. lepidota) using liquid chromatography-quadrupole time of flig. Journal of Agricultural and Food Chemistry. https://doi.org/10.1016/j.jfca.2022.104679.

Streptomyces distallicus, a potential microbial biolarvicide - (Abstract Only)

Phytochemical variability of essential oils of two Balkan endemic species Satureja pilosa Velen. and S. kitaibelii Wierzb. ex Heuff. (Lamiaceae) Reprint Icon - (Peer Reviewed Journal)
Zheljazkov, V.D., Semerdjieva, I.B., Cantrell, C.L., Astatkie, T., Acimovic, ¿. 2022. Phytochemical variability of essential oils of two Balkan endemic species Satureja pilosa Velen. and S. kitaibelii Wierzb. ex Heuff. (Lamiaceae). Molecules. https://doi.org/10.3390/molecules27103153.

Agronomy, chemical analysis, and antidiabetic activity of basil (Ocimum species) Reprint Icon - (Peer Reviewed Journal)
Wang, M., Cantrell, C.L., Matthews, S.T., Paudel, P., Lee, J., Mentreddy, S.R. 2022. Agronomy, chemical analysis, and antidiabetic activity of basil (Ocimum species). Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acsfoodscitech.2c00100?urlappend=%3Fref%3DPDF&jav=VoR&rel=cite-as.

Essential oil content, composition, and bioactivity of sagebrush species in the Bighorn Mountains Reprint Icon - (Peer Reviewed Journal)
Zheljazkov, V.D., Cantrell, C.L., Jeliazkova, E.L., Astatkie, T., Schlegel, V. 2022. Sagebrush species of the U.S. Bighorn Mountains: essential oil content, composition, and bioactivity. Plants. https://doi.org/10.3390/plants11091228.

Synthesis of 3,4,5-trisubstituted isoxazoles in water via a [3+2]-cycloaddition of nitrile oxides and 1,3-diketones, ß-ketoesters, or ß-ketoamides: Base-mediated and keto-enol-controlled mechanism. Reprint Icon - (Peer Reviewed Journal)
Hossain, M., Khan, M.H., Kim, S., Le, H.V. 2022. Synthesis of 3,4,5-trisubstituted isoxazoles in water via a [3+2]-cycloaddition of nitrile oxides and 1,3-diketones, ß-ketoesters, or ß-ketoamides: Base-mediated and keto-enol-controlled mechanism.. Beilstein Journal of Organic Chemistry. https://doi.org/10.3762/bjoc.18.47.

A new gnidiflavanone-flavonol dimer and other constituents from Gnidia apiculata Reprint Icon - (Peer Reviewed Journal)
Kamau, R.W., Midiwo, J.O., Mgani, Q.A., Masila, V.M., Kumarihamy, M., Wang, M., Zhao, J., Muhamma, I. 2022. A new gnidiflavanone-flavonol dimer and other constituents from Gnidia apiculata. Natural Product Research. https://doi.org/10.1080/14786419.2022.2062349.

Novel dioxolane ring compounds for the management of phytopathogen diseases as ergosterol biosynthesis inhibitors: synthesis, biological activities and molecular docking Reprint Icon - (Peer Reviewed Journal)
Min, L., Wang, H., Bajsa Hirschel, J.N., Yu, C., Wang, B., Yao, M., Han, L., Cantrell, C.L., Duke, S.O., Sun, N., Liu, X. 2022. Novel dioxolane ring compounds for the management of phytopathogen diseases as ergosterol biosynthesis inhibitors: synthesis, biological activities and molecular docking. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acs.jafc.2c00541.

Bulk process for enrichment of capsinoids from capsicum fruit Reprint Icon - (Peer Reviewed Journal)
Cantrell, C.L., Jarret, R.L. 2022. Bulk process for enrichment of capsinoids from capsicum fruit. Processes. 10(2):305. https://doi.org/10.3390/pr10020305.

6,5-fused ring, C2-salvinorin ester, dual kappa and mu opioid receptor agonists as analgesics devoid of anxiogenic effects. Reprint Icon - (Peer Reviewed Journal)
Akins, N.S., Mishra, N., Harris, H.M., Dudhipala, N., Kim, S., Keasling, A.W., Zjawiony, J.K., Ashpole, N.M., Le, H.V. 2022. 6,5-fused ring, C2-salvinorin ester, dual kappa and mu opioid receptor agonists as analgesics devoid of anxiogenic effects.. ChemMedChem. https://doi.org/10.1002/cmdc.202100684.

Phytochemical investigation and reproductive capacity of the Bulgarian endemic plant species Marrubium friwaldskyanum Boiss. (Lamiaceae) Reprint Icon - (Peer Reviewed Journal)
Zheljazkov, V.D., Semerdjieva, I.B., Stevens, J.F., Wu, W., Cantrell, C.L., Yankova-Tsvetkova, E., Koleva-Valkova, L.H., Stoyanova, A., Astatkie, T. 2021. Phytochemical investigation and reproductive capacity of the Bulgarian endemic plant species Marrubium friwaldskyanum Boiss. (Lamiaceae). Journal of Agricultural and Food Chemistry. https://doi.org/10.3390/plants11010114.

Comparative analysis of five salvia species using LC-DAD-QToF Reprint Icon - (Peer Reviewed Journal)
Avula, B., Bae, J., Chittiboyinaa, A.A., Wang, Y., Wang, M., Srivedavyasasri, R., Ali, Z., Li, J., Wu, C., Khan, I.A. 2021. Comparative analysis of five salvia species using LC-DAD-QToF. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpba.2021.114520.

Jasmonates promote enhanced production of bioactive caffeoylquinic acid derivative in Eclipta prostrata (L.) L. hairy roots Reprint Icon - (Peer Reviewed Journal)
Maciel, G., Aparecida Lopes, A., Cantrell, C.L., De Castro Franca, S., Waleria Bertoni, B., Verginia Lourenco, M. 2021. Jasmonates promote enhanced production of bioactive caffeoylquinic acid derivative in Eclipta prostrata (L.) L. hairy roots. Plant Cell Tissue and Organ Culture. https://doi.org/10.1007/s11240-021-02201-4.

Are atranols the only skin sensitizers in oakmoss, a systematic investigation using non-animal methods Reprint Icon - (Peer Reviewed Journal)
Avonto, C., Chittiboyina, A.G., Khan, S.I., Dale, O.R., Parcher, J.F., Wang, M., Khan, I.A. 2020. Are atranols the only skin sensitizers in oakmoss, a systematic investigation using non-animal methods. Toxicology In Vitro. 70. Article e105053. https://doi.org/10.1016/j.tiv.2020.105053.

NMR technique and methodology in botanical health product analysis and quality control Reprint Icon - (Peer Reviewed Journal)
Zhao, J., Wang, M., Saroja, S.G., Khan, I.A. 2021. NMR technique and methodology in botanical health product analysis and quality control. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpba.2021.114376.

Analysis of docosanol using GC/MS: Method development, validation, and application to ex vivo human skin permeation studies Reprint Icon - (Peer Reviewed Journal)
Shankara, V., Wang, M., Ajjarapua, S., Kolimi, P., Avula, B., Murthy, R., Khan, I., Naraisimha, M. 2021. Analysis of docosanol using GC/MS: Method development, validation, and application to ex vivo human skin permeation studies. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpha.2021.08.004.

Discovery 5a-pregnan-2ß,3a-diol-20-one as a neuroHIV protective agent - (Abstract Only)

Chemical constituents and anti-gastric ulcer activity of essential oils of Alpinia officinarum (Zingiberaceae), Cyperus rotundus (Cyperaceae), and their herbal pair Reprint Icon - (Peer Reviewed Journal)
Huijuan, Q., Lin, K., Li, X., Ou, H., Tan, Y., Wang, M., Wei, N. 2021. Chemical constituents and anti-gastric ulcer activity of essential oils of Alpinia officinarum (Zingiberaceae), Cyperus rotundus (Cyperaceae), and their herbal pair. Chemistry and Biodiversity. https://doi.org/10.1002/cbdv.202100214.

Synthesis and antifungal activity evaluation of phloeodictine analogues Reprint Icon - (Peer Reviewed Journal)
Ravu, R., Jacob, M.R., Khan, S.I., Wang, M., Cao, L., Agarwal, A.K., Clark, A.M., Li, X. 2021. Synthesis and antifungal activity evaluation of phloeodictine analogues. Journal of Natural Products. 84,2129-2137. https://doi.org/10.1021/acs.jnatprod.1c00116.

Characterization of the allelopathic potential of sugarcane leaves and roots Reprint Icon - (Peer Reviewed Journal)
Hijano, N., Nepomuceno, M.P., Cantrell, C.L., Duke, S.O., Alves, P.L. 2021. Characterization of the allelopathic potential of sugarcane leaves and roots. Journal of Agricultural Chemistry and Environment. https://doi.org/10.4236/jacen.2021.103016.

(E)-2,6,10-Trimethyldodec-8-en-2-ol: An undescribed sesquiterpenoid from copaiba oil Reprint Icon - (Peer Reviewed Journal)
Hawwal, M.F., Ali, Z., Wang, M., Zhao, J., Lee, J., Fantoukh, O.I., Khan, I.A. 2021. (E)-2,6,10-Trimethyldodec-8-en-2-ol: An undescribed sesquiterpenoid from copaiba oil. Molecules. 2021, 26, 4456. https://doi.org/10.3390/molecules26154456.

Microbial transformation of some simple isoquinoline and benzyl isoquinoline alkaloids and molecular docking studies of the metabolites Reprint Icon - (Peer Reviewed Journal)
El-Aasr, M., Eliwa, D., Albadry, M.A., Ibrahim, A.S., Kabbash, A., Meepagala, K.M., Khan, I.A., Ross, S.A., Khan, S.I. 2021. Microbial transformation of some simple isoquinoline and benzyl isoquinoline alkaloids and molecular docking studies of the metabolites. Phytochemistry. https://doi.org/10.1016/j.phytochem.2021.112828.

Chemical profiling and characterization of anthraquinones from two Bulbine species and dietary supplements using liquid chromatography-high resolution mass spectrometry Reprint Icon - (Peer Reviewed Journal)
Avula, B., Bae, J., Wang, Y., Wang, M., Ali, Z., Khan, I.A. 2021. Chemical profiling and characterization of anthraquinones from two Bulbine species and dietary supplements using liquid chromatography-high resolution mass spectrometry. Nature Product Communications. https://doi.org/10.1093/jaoacint/qsab075.

A novel approach for lavender essential oil authentication and quality assessment Reprint Icon - (Peer Reviewed Journal)
Wang, M., Zhao, J., Ali, Z., Avonto, C., Khan, I. 2021. A novel approach for lavender essential oil authentication and quality assessment. Journal of Pharmaceutical and Biomedical Analysis. 199. Article e114050. https://doi.org/10.1016/j.jpba.2021.114050.

Quantitative determination and characterization of polyphenols from Cissus quadrangularis L. and dietary supplements using UHPLC-PDA-MS, LC-QToF and HPTLC Reprint Icon - (Peer Reviewed Journal)
Avula, B., Bae, J., Zhao, J., Wang, Y., Wang, M., Zhang, Z., Ali, Z., Khan, I. 2021. Quantitative determination and characterization of polyphenols from Cissus quadrangularis L. and dietary supplements using UHPLC-PDA-MS, LC-QToF and HPTLC. Journal of Pharmaceutical and Biomedical Analysis. https://doi.org/10.1016/j.jpba.2021.114036.

In silico and in vitro studies of isolated constituents from Callistemon citrinus leaves: Anti-microbial potential and inhibition of iNOS activity Reprint Icon - (Peer Reviewed Journal)
Abdelmalek, E.M., Zulfiqar, F., Albadry, M.A., Khan, S.I., Meepagala, K.M., Ramadan, M.A., Darwish, F.M., Assaf, M.H., Ross, S.A. 2021. In silico and in vitro studies of isolated constituents from Callistemon citrinus leaves: Anti-microbial potential and inhibition of iNOS activity. Phytochemistry. 185. https://doi.org/10.1016/j.phytochem.2021.112745.

Cross talk of cancer signaling pathways by cyclic hexapeptides and anthraquinones from Rubia cordifolia Reprint Icon - (Peer Reviewed Journal)
Balachandran, P., Ibrahim, M.A., Zhang, J., Wang, M., Pasco, D.S., Muhammad, I. 2021. Cross talk of cancer signaling pathways by cyclic hexapeptides and anthraquinones from Rubia cordifolia. Molecules. 26/735. https://doi.org/10.3390/molecules26030735.

Antimicrobial constituents from Machaerium Pers.: Inhibitory activities and synergism of machaeriols and machaeridiols against methicillin-resistant Staphylococcus aureus and Vancomycin-resistant Enterococcus faecium and perm Reprint Icon - (Peer Reviewed Journal)
Muhammad, I., Jacob, M.R., Ibrahim, M.A., Raman, V., Kumarihamy, M., Wang, M., Al-Adhami, T., Hind, C., Clifford, M., Martin, B., Sutton, M., Rahman, M., Zhao, J. 2020. Antimicrobial constituents from Machaerium Pers.: Inhibitory activities and synergism of machaeriols and machaeridiols against methicillin-resistant Staphylococcus aureus and Vancomycin-resistant Enterococcus faecium and perm. Molecules. 25/6000. https://doi.org/10.3390/molecules25246000.

Phenolic contents, chemical profiling, in silico and in vitro antiinflammatory and anticancer properties of Alnus nitida (Spach) Endl Reprint Icon - (Peer Reviewed Journal)
Shaukat, U., Ahemad, S., Wang, M., Khan, S.I., Ali, Z., Muhammad I, T.I., Abdallah, H.H., Khan, I.A., Saleem, M., Mahomoodally, M.F. 2021. Phenolic contents, chemical profiling, in silico and in vitro antiinflammatory and anticancer properties of Alnus nitida (Spach) Endl. South African Journal of Botany. 138:148-155. https://doi.org/10.1016/j.sajb.2020.12.010.

Newly generated Atractylon derivatives in the processed rhizomes of Atractylodes macrocephala Koidz Reprint Icon - (Peer Reviewed Journal)
Zhai, C., Zhao, J., Chittiboyina, A.G., Meng, Y., Wang, M., Khan, S.I., Khan, I.A. 2020. Newly generated Atractylon derivatives in the processed rhizomes of Atractylodes macrocephala Koidz. Molecules. https://doi.org/10.3390/molecules25245904.

Biotransformation of papaverine and in silico docking studies of the metabolites on human phosphodiesterase 10a Reprint Icon - (Peer Reviewed Journal)
Eliwa, D., Albadry, M.A., Ibrahim, A.S., Kabbash, A., Meepagala, K.M., Khan, I.A., El-Aasr, M., Ross, S.A. 2020. Biotransformation of papaverine and in silico docking studies of the metabolites on human phosphodiesterase 10a. Phytochemistry. https://doi.org/10.1016/j.phytochem.2020.112598.

Comparative study and quality evaluation regarding morphology characters, volatile constituents and triglycerides in seeds of five species used in traditional Chinese medicine Reprint Icon - (Peer Reviewed Journal)
Wei, N., Wang, M., Adams, S.J., Yu, P., Avula, B., Wang, Y., Pan, K., Wang, Y., Khan, I.A. 2020. Comparative study and quality evaluation regarding morphology characters, volatile constituents and triglycerides in seeds of five species used in traditional Chinese medicine. Journal of Pharmaceutical and Biomedical Analysis. 194. Article e113801. https://doi.org/10.1016/j.jpba.2020.113801.

Effects of the macroalga Asparagopsis taxiformis and oregano leaves on methane emission, rumen fermentation, and lactational performance of dairy cows Reprint Icon - (Peer Reviewed Journal)
Stefenoni, H., Räisänen, S., Cueva Welchez, S., Wasson, D., Lage, C., Melgar, A., Fetter, M., Smith, P., Hennessy, M., Vecchiarelli, B., Bender, J., Pitta, D., Cantrell, C.L., Yarish, C., Hristov, A. 2021. Effects of the macroalga Asparagopsis taxiformis and oregano leaves on methane emission, rumen fermentation, and lactational performance of dairy cows. Journal of Dairy Science. 104:4157-4173. https://doi.org/10.3168/jds.2020-19686.

Sesquiterpene-a-amino acid quaternary ammonium hybrids from Stereum complicatum (Steraceae) Reprint Icon - (Peer Reviewed Journal)
Perera, W.H., Meepagala, K.M., Duke, S.O. 2020. Sesquiterpene-a-amino acid quaternary ammonium hybrids from Stereum complicatum (Steraceae). Biochemical Systematics and Ecology. 93,104176. https://doi.org/10.1016/j.bse.2020.104176.

Effects of Euphorbia umbellata extracts on complement activation and chemotaxis of neutrophils Reprint Icon - (Peer Reviewed Journal)
De Oliveira, T.L., Fontana, P.D., Bavia, L., Cruz, L., Crisma, A.R., Sassaki, G.L., Menezes, L.R., Wang, M., Beltrame, F., Messias-Reason, I.J. 2020. Effects of Euphorbia umbellata extracts on complement activation and chemotaxis of neutrophils. Journal of Ethnopharmacology. 265/113348. https://doi.org/10.1016/j.jep.2020.113348.