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ARS Home » Northeast Area » Orient Point, New York » Plum Island Animal Disease Center » Foreign Animal Disease Research » Research » Research Project #438304

Research Project: Development of Synthetic African Swine Fever Viruses to Determine the Role of Structural Viral Proteins

Location: Foreign Animal Disease Research

Project Number: 8064-32000-063-017-S
Project Type: Non-Assistance Cooperative Agreement

Start Date: Jun 1, 2020
End Date: May 31, 2022

This collaborative agreement seeks to design and synthesize synthetic DNA encoding for African swine fever virus to be used for creating recombinant ASFV.

African Swine Fever (ASF) is a large DNA virus of approximately 180kb. The ASFV-G genome will be synthesized from de-novo synthesis, using patented methods from CodexDNA, containing a fluorescent marker. Mutants will also be made changing particular genes from genotype II to a different genotype. The DNA will then be used along with techniques involving ARS-PIADC's propriety helper virus to create infectious ASFV virus from de-novo synthesis.