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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » Research » Research Project #437948

Research Project: Rapid Evolution of Influenza A Viruses in Swine Results in Zoonotic Viruses with Human Pandemic Potential

Location: Virus and Prion Research

Project Number: 5030-32000-120-030-I
Project Type: Interagency Reimbursable Agreement

Start Date: Mar 6, 2020
End Date: Sep 30, 2021

Objective:
Objective: Identify influenza A viruses (IAV) circulating in the swine population that are undergoing expanding genetic diversity as a greater risk to humans for zoonotic infections and pandemic potential.

Approach:
Viruses will be detected from swine farms, sequenced and the sequences analyzed by newly developed automated algorithms for genetic diversity, predicted antigenic advance, and patterns of reassortment. Genetic patterns will predict antigenic advance and increased replication and transmission in swine and in transmission from swine to ferrets to assess risk to the human population.