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ARS Home » Plains Area » Kerrville, Texas » Knipling-Bushland U.S. Livestock Insects Research Laboratory » LAPRU » Research » Research Project #437786

Research Project: Innovative Technologies to Minimize the Risk for the Re-Emergence of Bovine Babesiosis in the U.S.

Location: Livestock Arthropod Pests Research

Project Number: 3094-32000-042-059-R
Project Type: Reimbursable Cooperative Agreement

Start Date: Oct 1, 2019
End Date: Dec 31, 2021

Objective:
Adapt genomic approaches to analyze the CFT and Babesia genomes to identify vaccine candidates for highly efficient blockage of BB transmission by CFT to cattle.

Approach:
Reverse vaccinology will be applied to accomplish the main objective. As compared to conventional vaccinology, reverse vaccinology is based on genomic approaches to accelerate vaccine research and development. Bioinformatic algorithms will be applied to mine Babesia and CFT genomic sequence databases to identify candidate vaccine antigens. Biotechnology will be used to produce recombinant vaccine antigens based on selected nucleic acid sequence data. Recombinant vaccine antigens will be tested for their ability to block Babesia transmission to cattle.