Project Number: 6040-32000-066-64-S
Project Type: Non-Assistance Cooperative Agreement
Start Date: Jun 1, 2020
End Date: Apr 30, 2021
Determine the role of infectious bronchitis virus as an enhancer of pathogenicity through altering broiler chicken susceptibility and disease severity to low and high pathogenicity avian influenza viruses.
Infection and pathogenesis studies will be conducted in commercial broiler chickens. The chickens will be infected with a field isolate of infectious bronchitis virus (IBV) followed by challenge with low pathogenicity avian influenza virus H5N2 from Mexico or high pathogenicity avian influenza viruses. The birds will be assessed up or down regulation of genes that impact innate immune responses, and gross and microscopic lesions will be examined to determine if IBV increases disease severity through negatively impacting innate immune response or through direct alterations to respiratory epithelial barrier. Assessment of the secondary role of local bacterial flora will be accomplished.