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ARS Home » Pacific West Area » Pullman, Washington » Animal Disease Research » Research » Research Project #437260

Research Project: Efficacy of Bm86 Vaccine in Horses for Controlling Rhipicephalus Infestation

Location: Animal Disease Research

Project Number: 2090-32000-039-36-I
Project Type: Interagency Reimbursable Agreement

Start Date: Jul 16, 2019
End Date: Sep 30, 2021

Objective:
1) To immunize horses with BM86 protein and determine antibody reactivity against native tick proteins and 2) to test the efficacy of anti-BM86 antibodies in controlling tick infestation.

Approach:
Alternative methods to control tick infestation on horses are urgently needed. We propose to test if anti-BM86 can control tick infestation on horses immunized with BM86 vaccine from cooperator. To test this hypothesis, two groups of 5 horses will be used. Group 1 will be immunized with BM86 provided by cooperator and group 2 will be a control group. After determining antibody titer, Rhipicephalus ticks will be applied under a cloth patch and the infestation will be observed weekly. Engorged female ticks will be collected and oviposition, hatchability and viability of larvae will be compared between the two groups.