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ARS Home » Northeast Area » Beltsville, Maryland (BHNRC) » Beltsville Human Nutrition Research Center » Diet, Genomics and Immunology Laboratory » Research » Research Project #437064

Research Project: Study of Nutrients Gene Interaction

Location: Diet, Genomics and Immunology Laboratory

Project Number: 8040-51530-057-12-I
Project Type: Interagency Reimbursable Agreement

Start Date: Aug 13, 2019
End Date: Aug 12, 2020

Objective:
To elucidate the mechanisms underlaying cancer protective effects of the cruciferous vegetable-derived compound Indole-3-carbinol (I3C).

Approach:
Identify and validate specific T cell populations (ex. Cytotoxic T cell, T-reg etc.) affected by dietary I3C. The ultimate goal is to examine how I3C modulates these T cell subsets in a C rodentium infected mouse model. ARS hypothesized that I3C could protect against C rodentium-induced inflammation. Therefore, ARS will evaluate the effect of I3C on the relevant peripheral immune-regulating mechanisms in C rodentium-infected mice.