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ARS Home » Nutrition, Food Safety/Quality » Research » Research Project #436772

Research Project: Evidence Scanning for Dietary Reference Intake Nutrients

Location: Nutrition, Food Safety/Quality

Project Number: 0204-41510-001-95-G
Project Type: Grant

Start Date: Aug 1, 2020
End Date: Jul 31, 2021

Objective:
Most DRI values were established 20 years ago and have not been updated. A working group of sponsoring federal agencies has concluded that evidence scanning of relevant biomedical literature is needed to determine which nutrients should be assessed for revision of recommendations on intake. The NAS Food & Nutrition Board has developed a paradigm to accomplish this and has staff experienced with its application. A committee of subject matter experts will be constituted to present the compiled research to Federal sponsors (ARS and FDA as representatives of all Federal agencies) so they can make an informed decision about whether specific nutrients need to be revised.

Approach:
An ad hoc committee under the auspices of The National Academies of Sciences, Engineering, and Medicine will be convened to develop a framework for a selected nutrient that is based on the generic analytic framework for Dietary Reference Intakes (DRIs) to assess the relation of nutrient intake (exposure) to health outcomes. The committee will build on the methodology for evidence scanning of nutrients (which have existing DRIs) to further determine whether there is new and relevant knowledge available that may merit a formal reexamination of DRIs for a selected nutrient. The committee will carry out a literature search and evidence scan of the peer-reviewed published literature on indicators of nutritional requirements, toxicity and chronic disease risk reduction for a selected DRI nutrient. To carry out the scan the committee will review, interpret, and apply, as needed, the current DRI framework and evidence scanning methodology for a selected nutrient. The committee will develop pre-specified criteria; identify health outcomes indicators related to the nutrient(s) of interest including, as appropriate, indictors of physiological requirement, toxicity, and chronic disease risk, and assess the evidence for dose response or other relevant relationships between health outcome(s) and dietary intake. A one-half day web-based open meeting will be convened with subject matter experts in a discussion of relevant issues. The final product will be a brief summary of the methodology used to conduct the evidence scan, a table of the reviewed studies, and the committee’s assessment of the tabulated evidence. The final product will be a brief report that will serve as a template for use in informing development of future dietary reference intake values. The committee's final product will be reviewed in accordance with institutional requirements.