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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Research Project #436330

Research Project: Nutrition, Sarcopenia, Physical Function, and Skeletal Muscle Capacity During Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Effects of low doses of L-carnitine tartrate and lipid multi-particulate formulated creatine monohydrate on muscle protein synthesis in myoblasts and bioavailability in humans and rodents Reprint Icon - (Peer Reviewed Journal)
Fielding, R.A., Rivas, D.A., Grosicki, G.J., Ezzyat, Y., Ceglia, L., Price, L., Orhan, C., Sahin, K., Fowler, K., White, T., Durkee, S., Kritsch, K., Bellamine, A. 2021. Effects of low doses of L-carnitine tartrate and lipid multi-particulate formulated creatine monohydrate on muscle protein synthesis in myoblasts and bioavailability in humans and rodents. Nutrients. 13(11):3985. https://doi.org/10.3390/nu13113985.

miR-19b-3p is associated with a diametric response to resistance exercise in older adults and regulates skeletal muscle anabolism via PTEN inhibition Reprint Icon - (Peer Reviewed Journal)
Rivas, D.A., Peng, F., Benard, T., Sanchez Ramos da Silva , A., Fielding, R.A., Margolis, L. 2021. miR-19b-3p is associated with a diametric response to resistance exercise in older adults and regulates skeletal muscle anabolism via PTEN inhibition. American Journal of Physiology - Cell Physiology. 321(6):C977-C991. https://doi.org/10.1152/ajpcell.00190.2021.

A whole-grain diet increases whole-body protein balance compared to a macronutrient-matched refined-grain diet Reprint Icon - (Peer Reviewed Journal)
Mey, J.T., Godin, J., Scelsi, A.R., Kullman, E.L., Malin, S.K., Yang, S., Floyd, Z.E., Poulev, A., Fielding, R.A., Ross, A.B., Kirwan, J.P. 2021. A whole-grain diet increases whole-body protein balance compared to a macronutrient-matched refined-grain diet. Current Developments in Nutrition. 5:nzab121. https://doi.org/10.1093/cdn/nzab121.

International exercise recommendations in older adults (ICFSR): Expert consensus guidelines Reprint Icon - (Other)
Izquierdo, M., Merchant, R.A., Morley, J.E., Anker, S.D., Aprahamian, I., Arai, H., Aubertin-Leheudre, M., Bernabei, R., Cadore, E.L., Cesari, M., Chen, L., De Souto, B.P., Duque, G., Ferrucci, L., Fielding, R.A., Garcia-Hermoso, A., Gutierrez-Robledo, L.M., Harridge, S., D.R., Kirk, B., Kritchevsky, S.B., Landi, F., Lazarus, N., Martin, F., Marzetti, E., Pahor, M., Ramirez-Velez, R., Rodriguez-Manas, L., Rolland, Y., Ruiz, J.G., Theou, O., Villareal, D.T., Waters, D.L., Won Won, C., Woo, J., Vellas, B., Fiatrone, S.A. 2021. International exercise recommendations in older adults (ICFSR): Expert consensus guidelines . Journal of Nutrition Health and Aging. 25(7):824-853. https://doi.org/10.1007/s12603-021-1665-8.

Nutritional mediators of cellular decline and mitochondrial dysfunction in older adults Reprint Icon - (Review Article)
Guralnik, J.M., Feige, J.N., Singh, A., Fielding, R.A. 2021. Nutritional mediators of cellular decline and mitochondrial dysfunction in older adults. Geriatrics. 6(2):37. https://doi.org/10.3390/geriatrics6020037.

Effects of physical and cognitive training on gait speed and cognition in older adults: A randomized controlled trial Reprint Icon - (Peer Reviewed Journal)
Sipila, S., Tirkkonnen, A., Savikangas, T., Hanninen, T., Laukkanen, P., Alen, M., Fielding, R.A., Kivipelto, M., Kulmala, J., Rantanen, T., Sihvonen, S.E., Sillanpaa, E., Stigsdotter-Neely, A., Tormakangas, T. 2021. Effects of physical and cognitive training on gait speed and cognition in older adults: A randomized controlled trial. Scandinavian Journal of Medicine & Science in Sports. 31(7):1518-1533. https://doi.org/10.1111/sms.13960.

Urban-rural differences in the prevalence of muscle weakness and slow gait speed: A cross-sectional analysis from the NHANES (2001-2002 and 2011-2014) Reprint Icon - (Peer Reviewed Journal)
Aziz, J.J., Reid, K.F., Batsis, J.A., Fielding, R.A. 2021. Urban-rural differences in the prevalence of muscle weakness and slow gait speed: A cross-sectional analysis from the NHANES (2001-2002 and 2011-2014). Journal of Aging Research & Lifestyle. 10:19-25. https://doi.org/10.14283/jarlife.2021.4.

Sarcopenia definitions as predictors of fracture risk independent of FRAX, falls, and BMD in the osteoporotic fractures in men (MrOS) study: a meta-analysis Reprint Icon - (Peer Reviewed Journal)
Harvey, N.C., Orwoll, E., Kwok, T., Karlsson, M.K., Rosengren, B.E., Ribom, E., Cauley, J.A., Cawthon, P.M., Ensrud, K., Liu, E., Cruz-Jentoft, A.J., Fielding, R.A., Cooper, C., Kanis, J.A., Lorentzon, M., Ohlsson, C., Mellstrom, D., Johansson, H., Mccloskey, E. 2021. Sarcopenia definitions as predictors of fracture risk independent of FRAX, falls, and BMD in the osteoporotic fractures in men (MrOS) study: a meta-analysis. Journal of Bone and Mineral Research. 36(7):1235-1244. https://doi.org/10.1002/JBMR.4293.

Elevated IL-6 and CRP levels are associated with incident self-reported major mobility disability: A pooled analysis of older adults with slow gait speed Reprint Icon - (Peer Reviewed Journal)
Beavers, D.P., Kritchevsky, S.B., Gill, T.M., Ambrosius, W.T., Anton, S.D., Fielding, R.A., King, A.C., Rejeski, W., Lovato, L., McDermott, M.M., Newman, A.B., Pahor, M., Walkup, M.P., Tracy, R.P., Manini, T.M. 2021. Elevated IL-6 and CRP levels are associated with incident self-reported major mobility disability: A pooled analysis of older adults with slow gait speed. Journals of Gerontology. https://doi.org/10.1093/gerona/glab093.

Identifying biomarkers for biological age: geroscience and the ICFSR task force Reprint Icon - (Review Article)
Lebrasseur, N.K., De Cabo, R., Fielding, R.A., Ferrucci, L., Rodriguez-Manas, L., Vina, J., Vellas, B. 2021. Identifying biomarkers for biological age: geroscience and the ICFSR task force. The Journal of Frailty and Aging. 10:196-201. https://doi.org/10.14283/jfa.2021.5.

Relationships between level and change in sarcopenia and other body composition components and adverse health outcomes: findings from the health, aging, and body composition study Reprint Icon - (Peer Reviewed Journal)
Westbury, L.D., Syddall, H.E., Fuggle, N.R., Dennison, E.M., Harvey, N.C., Cauley, J.A., Shiroma, E.J., Fielding, R., Newman, A.B., Cooper, C. 2020. Relationships between level and change in sarcopenia and other body composition components and adverse health outcomes: findings from the health, aging, and body composition study. Calcified Tissues International. 108:302-313. https://doi.org/10.1007/s00223-020-00775-3.

Update on the ESCEO recommendation for the conduct of clinical trials for drugs aiming at the treatment of sarcopenia in older adults Reprint Icon - (Peer Reviewed Journal)
Reginster, J., Beaudart, C., Al-Daghri, N., Avouac, B., Bauer, J., Bere, N., Bruyere, O., Cerreta, F., Cesari, M., Rosa, M., Cooper, C., Cruz Jentoft, A.J., Dennison, E., Geerinck, A., Gielen, E., Landi, F., Laslop, A., Maggi, S., Concepcion Prieto, Y., Rizzoli, R., Sundseth, H., Sieber, C., Trombetti, A., Vellas, B., Veronese, N., Visser, M., Vlaskovska, M., Fielding, R.A. 2020. Update on the ESCEO recommendation for the conduct of clinical trials for drugs aiming at the treatment of sarcopenia in older adults. Aging Clinical Experimental Research. https://doi.org/10.1007/s40520-020-01663-4.

The relationship between interleukin-6 levels and physical performance in mobility-limited older adults with chronic low-grade inflammation: the ENRGISE pilot study Reprint Icon - (Peer Reviewed Journal)
Custodero, C., Anton, S.D., Beavers, D.P., Mankowski, R.T., Lee, S.A., McDermott, M.M., Fielding, R.A., Newman, A.B., Tracy, R.P., Kritchevsky, S.B., Ambrosius, W.T., Pahor, M., Manini, T.M. 2020. The relationship between interleukin-6 levels and physical performance in mobility-limited older adults with chronic low-grade inflammation: the ENRGISE pilot study. Archives of Gerontology and Geriatrics. 90. Article 104131. https://doi.org/10.1016/j.archger.2020.104131.

Putative cut-points in sarcopenia components and incident adverse health outcomes: an SDOC analysis Reprint Icon - (Peer Reviewed Journal)
Cawthon, P.M., Manini, T., Patel, S.M., Newman, A., Travison, T., Kiel, D.P., Santanasto, A.J., Ensrud, K.E., Xue, Q., Shardell, M., Duchowny, K., Erlandson, K.M., Pencina, K.M., Fielding, R.A., Magaziner, J., Kwok, T., Karlsson, M., Ohlsson, C., Mellstrom, D., Hirani, V., Ribom, E., Correa-De-Araujo, R., Bhasin, S. 2020. Putative cut-points in sarcopenia components and incident adverse health outcomes: an SDOC analysis. Journal of the American Geriatrics Society. 68:1429-1437. https://doi.org/10.1111/jgs.16517.

Application of selected muscle strength and body mass cut points for the diagnosis of sarcopenia in men and women with or at risk for HIV infection Reprint Icon - (Peer Reviewed Journal)
Erlandson, K.M., Travison, T.G., Zhu, H., Magaziner, J., Correa-De-Araujo, R., Cawthon, P.M., Bhasin, S., Manini, T., Fielding, R.A., Palella, F.J., Kingsley, L., Lake, J.E., Sharma, A., Tien, P.C., Weber, K.M., Yin, M.T., Brown, T.T. 2020. Application of selected muscle strength and body mass cut points for the diagnosis of sarcopenia in men and women with or at risk for HIV infection. Journal of Gerontology Medical Science. 75(7):1338-1345. https://doi.org/10.1093/gerona/glaa083.

Identification of sarcopenia components that discriminate slow walking speed: a pooled data analysis Reprint Icon - (Peer Reviewed Journal)
Manini, T.M., Patel, S., Newman, A.B., Travison, T.G., Kiel, D.P., Shardell, M., Pencina, K., Wilson, K.E., Kelly, T.L., Masaro, J.M., Fielding, R.A., Magaziner, J., Correa-de-Araujo, R., Kwok, T.C., Hirani, V., Karlsson, M.K., D'Agostino, R., Mellstrom, D., Ohlsson, C., Ribom, E., Jordan, J.M., Bhasin, S., Cawthon, P.M. 2020. Identification of sarcopenia components that discriminate slow walking speed: a pooled data analysis. Journal of the American Geriatrics Society. 68(7):1419-1428. https://doi.org/10.1111/jgs.16524.

Application of cut-points for low muscle strength and lean mass in mobility-limited older adults Reprint Icon - (Peer Reviewed Journal)
Grosicki, G., Travison, T.G., Zhu, H., Magaziner, J., Binder, E.F., Pahor, M., Correa-De-Araujo, R., Cawthon, P.M., Bhasin, S., Orwig, D., Greenspan, S., Manini, T., Massaro, J., Santanasto, A., Patel, S., Fielding, R.A. 2020. Application of cut-points for low muscle strength and lean mass in mobility-limited older adults. Journal of the American Geriatrics Society. 68:1445-1453. https://doi.org/10.1111/jgs.16525.

Sarcopenia definition: The position statements of the sarcopenia definition and outcomes consortium Reprint Icon - (Peer Reviewed Journal)
Bhasin, S., Travison, T.G., Manini, T.M., Patel, S., Pencina, K.M., Fielding, R.A., Magaziner, J.M., Newman, A.B., Kiel, D.P., Cooper, C., Guralnik, J.M., Cauley, J.A., Arai, H., Clark, B.C., Landi, F., Schaap, L.A., Pereira, S.L., Rooks, D., Woo, J., Woodhouse, L.J., Binder, E., Brown, T., Shardell, M., Xue, Q., D'Agostino Sr., R.B., Orwig, D., Grosicki, G., Correa-de-Araujo, R., Cawthon, P.M. 2020. Sarcopenia definition: The position statements of the sarcopenia definition and outcomes consortium. Journal of the American Geriatrics Society. 68:1410-1418. https://doi.org/10.1111/jgs.16372.

Application of SDOC cut points for low muscle strength for recovery of walking speed after hip fracture Reprint Icon - (Peer Reviewed Journal)
Orwig, D., Magaziner, J., Fielding, R.A., Zhu, H., Binder, E.F., Cawthon, P., Bhasin, S., Correa-De-Araujo, R., Manini, T., Patel, S., Shardell, M., Travison, T.G. 2020. Application of SDOC cut points for low muscle strength for recovery of walking speed after hip fracture. Journal of Gerontology Medical Science. 75(7):1379-1385. https://doi.org/10.1093/gerona/glaa076.

Sarcopenia definition & outcomes consortium defined low grip strength in two cross-sectional, population-based cohorts Reprint Icon - (Peer Reviewed Journal)
Patel, S.M., Duchowny, K.A., Kiel, D.P., Correa-de-Araujo, R., Fielding, R.A., Travison, T., Magaziner, J., Manini, T., Xue, Q., Newman, A.B., Pencina, K.M., Santanasto, A., Bhasin, S., Cawthon, P.M. 2020. Sarcopenia definition & outcomes consortium defined low grip strength in two cross-sectional, population-based cohorts. Journal of the American Geriatrics Society. https://doi.org/10.1111/jgs.16419.

Long term rates of change in musculoskeletal aging and body composition: findings from the Health, Aging and Body Composition Study Reprint Icon - (Peer Reviewed Journal)
Westbury, L.D., Syddall, H.E., Fuggle, N.R., Dennison, E.M., Cauley, J.A., Shiroma, E.J., Fielding, R.A., Newman, A.B., Cooper, C. 2020. Long term rates of change in musculoskeletal aging and body composition: findings from the Health, Aging and Body Composition Study. Calcified Tissue International. https://doi.org/10.1007/s00223-020-00679-2.

Associations of physical activity in detailed intensity ranges with body composition and physical function. a cross-sectional study among sedentary older adults Reprint Icon - (Peer Reviewed Journal)
Savikangas, T., Tirkkonen, A., Alen, M., Rantanen, T., Fielding, R.A., Rantalainen, T., Sipila, S. 2020. Associations of physical activity in detailed intensity ranges with body composition and physical function. a cross-sectional study among sedentary older adults. European Review of Aging and Physical Activity. 17:4. https://doi.org/10.1186/s11556-020-0237-y.

The role of the gut microbiome on skeletal muscle mass and physical function: 2019 update Reprint Icon - (Review Article)
Lustgarten, M. 2019. The role of the gut microbiome on skeletal muscle mass and physical function: 2019 update. Frontiers in Physiology. https://doi.org/10.3389/fphys.2019.01435.

AGS and NIA bench-to bedside conference summary: osteoporosis and soft tissue (muscle and fat) disorders Reprint Icon - (Proceedings)
Colon-Emeric, C., Whitson, H.E., Berry, S.D., Fielding, R.A., Houston, D.K., Kiel, D., Rosen, C., Seldeen, K.L., Volpi, E., White, J.P., Troen, B.R. 2019. AGS and NIA bench-to bedside conference summary: osteoporosis and soft tissue (muscle and fat) disorders. Journal of the American Geriatrics Society. https://doi.org/10.1111/jgs.16248.

ICFSR task force perspective on biomarkers for sarcopenia and frailty Reprint Icon - (Review Article)
Rodriguez-Manas, L., Araujo De Carvalho, I., Bhasin, S., Bischoff-Ferrara, H.A., Cesari, M., Evans, W., Hare, J.M., Pahor, M., Parini, A., Rolland, Y., Fielding, R.A., Watson, J., Vellas, B. 2019. ICFSR task force perspective on biomarkers for sarcopenia and frailty. The Journal of Frailty and Aging. 9(1):4-8. https://doi.org/10.14283/jfa.2019.32.

Impact of baseline fatigue on a physical ability intervention to prevent mobility disability Reprint Icon - (Peer Reviewed Journal)
Glynn, N.W., Gmelin, T., Santanasto, A.J., Lovato, L.C., Lange-Maia, B.S., Nicklas, B.J., Fielding, R.A., Manini, T.M., Myers, V.H., De Rekeneire, N., Spring, B.J., Pahor, M., King, A.C., Rejeski, W., Newman, A.B. 2019. Impact of baseline fatigue on a physical ability intervention to prevent mobility disability. Journal of the American Geriatrics Society. https://doi.org/10.1111/jgs.16274.

The clinical impact and biological mechanisms of skeletal muscle aging Reprint Icon - (Review Article)
Aversa, Z., Zhang, X., Fielding, R.A., Lanza, I., Lebrasseur, N.K. 2019. The clinical impact and biological mechanisms of skeletal muscle aging. Bone. 127:26-36. https://doi.org/10.1016/j.bone.2019.05.021.

The effects of tai chi mind-body approach on the mechanisms of gulf war illness: an umbrella review Reprint Icon - (Review Article)
Reid, K.F., Bannuru, R.R., Wang, C., Mori, D.L., Niles, B.L. 2019. The effects of tai chi mind-body approach on the mechanisms of gulf war illness: an umbrella review. Integrative Medicine Research. 8(3):167-172. https://doi.org/10.1016/j.imr.2019.05.003.

Comparative effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on response to a physical activity intervention in older adults: results from the Lifestyle Interventions for Elders study Reprint Icon - (Peer Reviewed Journal)
Brown, J.D., Smith, S.M., Strotmeyer, E.S., Kritchevsky, S.B., Gill, T.M., Blair, S.N., Fielding, R.A., Buford, T.W., Pahor, M., Manini, T.M. 2019. Comparative effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on response to a physical activity intervention in older adults: results from the Lifestyle Interventions for Elders study. Journals of Gerontology. https://doi.org/10.1093/gerona/glz120.

Is there enough evidence for osteosarcopenic obesity as a distinct entity? A critical literature review Reprint Icon - (Review Article)
Bauer, J.M., Cruz-Jentoft, A.J., Fielding, R.A., Kanis, J.A., Reginster, J., Bruyere, O., Cesari, M., Chapurlat, R., Al-Daghri, N., Dennison, E., Kaufman, J., Landi, F., Laslop, A., Locquet, M., Maggi, S., Mccloskey, E., Perna, S., Rizzoli, R., Rolland, Y., Rondanelli, M., Szulc, P., Vellas, B., Vlaskovska, M., Cooper, C. 2019. Is there enough evidence for osteosarcopenic obesity as a distinct entity? A critical literature review. Calcified Tissue International. 105(2):109-124. https://doi.org/10.1007/s00223-019-00561-w.

Highlights from the 2019 International Congress on Frailty and Sarcopenia Research Reprint Icon - (Other)
Maltais, M., Aubertin-Leheudre, M., Dray, C., Fielding, R.A., Rolland, Y., Cesare, M., Vellas, B. 2019. Highlights from the 2019 International Congress on Frailty and Sarcopenia Research. The Journal of Frailty and Aging. 8(3):117-119. https://doi.org/10.14283/jfa.2019.13.