Location: Diet, Genomics and Immunology Laboratory2019 Annual Report
Objective 1: Determine if polyphenol rich diets prevent microbiome dysbiosis, inappropriate activation of Toll and NOD-like receptor (TLR/NOD-like receptors) and reduce the severity of colitis in pigs. [NP107, C3, PS3B] Objective 2: Compare consumption of polyphenol-rich foods combined with probiotics early in life for amelioration of systemic inflammation induced by a westernized high fat diet. [NP107, C3, PS3B, C4, PS4A] Objective 3: Establish if consumption of polyphenol-rich foods will normalize westernized high fat diet-induced microbiome dysbiosis and prevent generalized inflammation. [NP107, C3, PS3B C4, PS4A]
The overall goal of the proposed research is to understand the complex interactions between diet, gut microbiome and host responses that are critical for the prevention of diseases associated with poor diet choices. The objective is to use a human-relevant pig model to understand mechanisms of intestinal dysregulation during consumption of a westernized-diet, which is strongly associated with obesity and related metabolic diseases, and to evaluate the incorporation of dietary probiotics, fruits and vegetables as an approach to attenuate the adverse consequences of consuming a westernized-diet. To achieve this goal, we propose to study the time-dependent changes in broad host health biomarkers within the immunome, microbiome and metabolome, and the dietary interventions that modulate these biomarkers. Our central hypothesis is that a modified westernized dietary pattern that contains recommended levels of fruits and vegetables will promote a healthier host microbiome due a polyphenol-induced prebiotic effect and anti-inflammatory responses.
This report is for a new NP107 OSQR approved project entitled “Polyphenol-Rich Foods and Promotion of Intestinal Health.” Animal Care and Use protocol for the project plan has been written and submitted for Institution approval. See Final Report for 8040-51530-056-00D for 2019 accomplishments.