Location: Animal Metabolism-Agricultural Chemicals Research
Project Number: 3060-32420-001-020-S
Project Type: Non-Assistance Cooperative Agreement
Start Date: Mar 11, 2019
End Date: Sep 30, 2019
Objective:
The Food Safety and Inspection Service (FSIS) is the public health agency in the U.S. Department of Agriculture responsible for ensuring that the nation's commercial supply of meat, poultry, and egg products is safe, wholesome, and correctly labeled and packaged. A New Mexico dairy farmer’s herd of approximately 5,000 dairy cattle (the "Highland" herd) consumed drinking water contaminated with perfluoroalkyl substances (PFAS) including perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS). These chemicals are used as foaming agents for fire retardants, and they bioaccumulate in humans and animals resulting in potential reproductive and developmental issues. The US Environmental Protection Agency (EPA) formed a scientific advisory committee in 2005 and determined that PFOA is “likely to be carcinogenic in humans.”
In October 2018, the Food and Drug Administration (FDA) tested and determined that the milk from the New Mexico herd was adulterated, and FDA subsequently notified FSIS of their findings in early November. Upon receiving FDA’s notification, FSIS notified state animal health officials that cattle from Highland Dairy should not be shipped to a federally inspected establishment and are not eligible to be slaughtered and processed for human food. Since then, FSIS has been working to address the disposition of the meat from these animals in an effort to bring some resolution to the dairy producer. Currently the baseline PFAS concentration in beef produced in the United States is unknown. Canada and the European Union have conducted studies that estimate meat at retail to contain approximately 0.5 to 0.75 ppb of PFAS.
The objective of this agreement is to generate baseline serum and tissue residue data in cattle exposed to a water source contaminated with PFAs and to obtain kinetic data describing the depletion of PFAs from unintentionally exposed food animals.
Approach:
1) The university will procure 30 cattle from the owner of the contaminated dairy herd.
2) Tissue samples (liver, kidney, muscle, blood) will be collected from approximately 20 animals (young, lactating, and mature, dry cows) and shipped to the ARS laboratory for residue analysis. A subset of the tissue samples will be sent to the USDA FSIS Eastern lab for pathology/histology assessments.
3) Ten cattle (young, lactating, and mature, dry cows) will be housed at university animal facilities. Blood/tissue samples will be obtained by the university personnel at approximately 2 to 5-week intervals over a period of one year to assess pharmacokinetic parameters associated with PFAs depletion. Plasma samples will be sent to the ARS laboratory in Fargo for residue analyses. A subset of tissue samples, collected at agreed upon intervals, will be sent to ARS lab for residue testing and a subset to the FSIS Eastern lab for pathology/histology studies.
