Research Project: Nutrition, Immune and Inflammatory Responses, and Related Diseases

Location: Jean Mayer Human Nutrition Research Center On Aging

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Study protocol for a zinc intervention in the elderly for prevention of pneumonia (ZIPP), a randomized, placebo-controlled, double-blind clinical pilot trial - (Peer Reviewed Journal)
Ortega, E.F., Wu, D., Guo, W., Meydani, S., Panda, A. 2024. Study protocol for a zinc intervention in the elderly for prevention of pneumonia (ZIPP), a randomized, placebo-controlled, double-blind clinical pilot trial. Frontiers in Nutrition. https://doi.org/10.3389/fnut.2024.1356594.

Life-long consumption of high level of fruits and vegetables reduces tumor incidence and extends median lifespan in mice - (Peer Reviewed Journal)
Guo, W., Ortega, E., Wu, D., Li, L., Bronson, R.T., Boehm, S., Meydani, S.N. 2023. Life-long consumption of high level of fruits and vegetables reduces tumor incidence and extends median lifespan in mice. Frontiers in Nutrition. https://doi.org/10.3389/fnut.2023.1286792.

Safe and effective delivery of supplemental iron to healthy adults: A two-phase, randomized, double-blind trial - the Safe Iron Study - (Peer Reviewed Journal)
Lewis, E., Ortega, E.F., Dao, M., Barger, K., Mason, J.B., Leong, J.M., Osburne, M.S., Magoun, L., Nepveux, F.J., Chishti, A.H., Schwake, C., Quyhn, A., Gilhooly, C.H., Petty, G., Guo, W., Matuszek, G.H., Pereira, D., Reddy, M., Wang, J., Wu, D., Meydani, S.N., Combs, G.F. 2023. Safe and effective delivery of supplemental iron to healthy adults: A two-phase, randomized, double-blind trial - the Safe Iron Study. Frontiers in Nutrition. https://doi.org/10.3389/fnut.2023.1230061.

Obesity, rather than high fat diet, exacerbates the outcome of influenza virus infection in influenza-sensitized mice - (Peer Reviewed Journal)
Guo, W., Wu, D., Li, L., Ding, S., Meydani, S.N. 2022. Obesity, rather than high fat diet, exacerbates the outcome of influenza virus infection in influenza-sensitized mice. Frontiers in Nutrition. https://doi.org/10.3389/fnut.2022.1018831.

Age-associated alterations in immune function and inflammation - (Review Article)
Lewis, E.D., Wu, D., Meydani, S.N. 2022. Age-associated alterations in immune function and inflammation. Progress in Neuropsychopharmacology & Biological Psychiatry. 118:110576. https://doi.org/10.1016/j.pnpbp.2022.110576.

Perspective: Role of micronutrients and omega-3 long-chain polyunsaturated fatty acids for immune outcomes of relevance to infections in older adults - a narrative review and call for action - (Review Article)
Eggersdorfer, M., Berger, M.M., Calder, P.C., Gombart, A.F., Ho, E., Laviano, A., Meydani, S.N. 2022. Perspective: Role of micronutrients and omega-3 long-chain polyunsaturated fatty acids for immune outcomes of relevance to infections in older adults - a narrative review and call for action. Advances in Nutrition. https://doi.org/10.1093/advances/nmac058.

Time-restricted feeding restores obesity-induced alteration in adipose tissue immune cell phenotype - (Peer Reviewed Journal)
Lee, Y., Kim, Y., Lee, M., Wu, D., Pae, M. 2021. Time-restricted feeding restores obesity-induced alteration in adipose tissue immune cell phenotype. Nutrients. 13(11):3780. https://doi.org/10.3390/nu13113780.

Stachyose inhibits vancomycin-resistant Enterococcus colonization and affects gut microbiota in mice - (Peer Reviewed Journal)
Zhu, S., Li, X., Song, L., Huang, Y., Xiao, Y., Chu, Q., Kang, Y., Duan, S., Wu, D., Ren, Z. 2021. Stachyose inhibits vancomycin-resistant Enterococcus colonization and affects gut microbiota in mice. Microbial Pathogenesis. 59:105094. https://doi.org/10.1016/j.micpath.2021.105094.

A murine model for the transition of Streptococcus pneumoniae from asymptomatic colonizer to systemic pathogen - (Peer Reviewed Journal)
Joma, B.H., Siwapornchai, N., Vanguri, V.K., Shrestha, A., Roggensack, S.E., Davidson, B.A., Tai, A.K., Hakansson, A.P., Meydani, S.N., Leong, J.M., Bou Ghanem, E.N. 2021. A murine model for the transition of Streptococcus pneumoniae from asymptomatic colonizer to systemic pathogen. American Society for Microbiology. https://doi.org/10.1128/IAI.00471-20.

A murine model for enhancement of Streptococcus pneumoniae pathogenicity upon viral infection and advanced age - (Peer Reviewed Journal)
Joma, B.H., Siwapornchai, N., Vanguri, V.K., Shrestha, A., Roggensack, S.E., Davidson, B.A., Tai, A.K., Hakansson, A.P., Meydani, S.N., Leong, J.M., Bou Ghanem, E.N. 2021. A murine model for enhancement of Streptococcus pneumoniae pathogenicity upon viral infection and advanced age. Infection and Immunity. 89(8):e00471-20. https://doi.org/10.1128/IAI.00471-20.

Browning white adipose tissue using adipose stromal cell-targeted resveratrol-loaded nanoparticles for combating obesity - (Peer Reviewed Journal)
Zu, Y., Zhao, L., Hao, L., Machref, Y., Zabet-Moghaddam, M., Keyel, P.A., Abbasi, M., Wu, D., Dawson, J.A., Zhang, R., Nie, S., Moustaid-Moussa, N., Kolonin, M.G., Daquinag, A.C., Brandi, L., Warraich, I., San Francisco, S.K., Sun, X., Fan, Z., Wang, S. 2021. Browning white adipose tissue using adipose stromal cell-targeted resveratrol-loaded nanoparticles for combating obesity. Journal of Controlled Release. 333:339-351. https://doi.org/10.1016/j.jconrel.2021.03.022.

Luteolin inhibits NLRP3 inflammasome activation via blocking ASC oligomerization - (Peer Reviewed Journal)
Nam Lee, M., Lee, Y., Wu, D., Pae, M. 2021. Luteolin inhibits NLRP3 inflammasome activation via blocking ASC oligomerization. Journal of Nutritional Biochemistry. 92:108614. https://doi.org/10.1016/j.jnutbio.2021.108614.

Vitamin D inhibits adipokine production and inflammatory signaling through the vitamin D receptor in human adipocytes - (Peer Reviewed Journal)
Nimitphong, H., Guo, W., Holick, M.F., Fried, S.K., Lee, M. 2021. Vitamin D inhibits adipokine production and inflammatory signaling through the vitamin D receptor in human adipocytes. Obesity. 29(3):562-568. https://doi.org/10.1002/oby.23109.

Dietary fruit and vegetable supplementation suppresses diet-induced atherosclerosis in LDL receptor knockout mice - (Peer Reviewed Journal)
Guo, W., Kim, S.H., Wu, D., Li, L., Ortega, E.F., Thomas, M., Meydani, S.N., Meydani, M. 2021. Dietary fruit and vegetable supplementation suppresses diet-induced atherosclerosis in LDL receptor knockout mice. Journal of Nutrition. 151(4):902-910. https://doi.org/10.1093/jn/nxaa410.

Macrophage LC3-associated phagocytosis is an immune defense against Streptococcus pneumoniae that diminishes with host aging - (Peer Reviewed Journal)
Inomata, M., Xu, S., Chandra, P., Meydani, S.N., Takemura, G., Philips, J.A., Leong, J.M. 2020. Macrophage LC3-associated phagocytosis is an immune defense against Streptococcus pneumoniae that diminishes with host aging. Proceedings of the National Academy of Sciences (PNAS). 117(52):33561-33569. https://doi.org/10.1073/pnas.2015368117.

A novel combination of fruits and vegetables prevents diet-induced hepatic steatosis and metabolic dysfunction in mice - (Peer Reviewed Journal)
Guo, W., Wu, D., Dao, M.C., Li, L., Lewis, E., Ortega, E.F., Eorn, H., Thomas, M., Nikolova-Karakashian, M., Meydani, M., Meydani, S.N. 2020. A novel combination of fruits and vegetables prevents diet-induced hepatic steatosis and metabolic dysfunction in mice. Journal of Nutrition. 150(11):2950-2960. https://doi.org/10.1093/jn/nxaa259.

Recent advances in nanoencapsulation of phytochemicals to combat obesity and its comorbidities - (Peer Reviewed Journal)
Goktas, Z., Zu, Y., Abbasi, M., Galyean, S., Wu, D., Fan, Z., Wang, S. 2020. Recent advances in nanoencapsulation of phytochemicals to combat obesity and its comorbidities. Journal of Agricultural and Food Chemistry. 68(31):8119-8131. https://doi.org/10.1021/acs.jafc.0c00131.

Supplementation with a novel combination of fruits and vegetables prevented high fat diet-induced cognitive impairment in mice - (Abstract Only)
Guo, W., Shukitt Hale, B., Wu, D., Li, L., Ortega, E.F., Liu, Y., Thomas, M., Nikolova-Karakashian, M., Meydani, M., Meydani, S.N. 2020. Supplementation with a novel combination of fruits and vegetables prevented high fat diet-induced cognitive impairment in mice [abstract]. Current Developments in Nutrition. https://doi.org/10.1093/cdn/nzaa057_023.

Strategies to prevent or remediate cancer- and treatment-related aging - (Review Article)
Guida, J.L., Agurs-Collins, T., Ahles, T.A., Campisi, J., Dale, W., Demark-Wahnefrie, W., Dietrich, J., Fuldner, R., Gallicchio, L., Green, P.A., Hurria, A., Janelsins, M.C., Jhappan, C., Kirkland, J.L., Kohanski, R., Longo, V., Meydani, S.N., Mohile, S., Niedernhofer, L.J., Nelson, C., Perna, F., Schadler, K.L., Scott, J.M., Schrack, J.A., Russell, T.P., Van Deursen, J., Ness, K.K. 2020. Strategies to prevent or remediate cancer- and treatment-related aging. Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/djaa060.

Prevention of non-alcoholic fatty liver disease by fruits and vegetables supplementation in mice is associated with their antioxidant property - (Abstract Only)
Guo, W., Wu, D., Li, L., Ortega, E.F., Liu, Y., Thomas, M., Nikolova-Karakashian, M., Meydani, M., Meydani, S.N. 2020. Prevention of non-alcoholic fatty liver disease by fruits and vegetables supplementation in mice is associated with their antioxidant property [abstract]. Current Developments in Nutrition. 4:1523. https://doi.org/10.1093/cdn/nzaa068_008.

Safe and effective delivery of supplemental iron to healthy older adults: the double-blind, randomized, placebo-controlled trial protocol of the Safe Iron Study - (Peer Reviewed Journal)
Lewis, E.D., Wu, D., Mason, J.B., Chishti, A.H., Leong, J.M., Barger, K., Meydani, S.N., Combs, G.F. 2019. Safe and effective delivery of supplemental iron to healthy older adults: the double-blind, randomized, placebo-controlled trial protocol of the Safe Iron Study. Gates Open Research. 3:1510. https://doi.org/10.12688/gatesopenres.13039.1.

Development and validation of a fecal extraction procedure for the assessment of multiple fecal biomarkers of intestinal inflammation - (Abstract Only)
Lewis, E., Guo, W., Li, L., Wu, D., Combs, G.F., Meydani, S.N. 2019. Development and validation of a fecal extraction procedure for the assessment of multiple fecal biomarkers of intestinal inflammation. Current Developments in Nutrition. 3(Suppl_1). Abstract No. P13-025-19. https://doi.org/10.1093/cdn/nzz036.P13-025-19.

Anti-atherogenic effects of CD36-targeted epigallocatechin gallate-loaded nanoparticles - (Peer Reviewed Journal)
Zhang, J., Nle, S., Zu, Y., Abbasi, M., Cao, J., Li, C., Wu, D., Labib, S., Brackee, G., Shen, C., Wang, S. 2019. Anti-atherogenic effects of CD36-targeted epigallocatechin gallate-loaded nanoparticles. Journal of Controlled Release. 303:263-273. https://doi.org/10.1016/j.jconrel.2019.04.018.

The effects of a high fat diet on measures of bone microarchitecture in mouse bones - (Abstract Only)
Munoz, J., Siebert, S., Guo, W., Lewis, E., Li, L., Wu, D., Meydani, S. 2019. The effects of a high fat diet on measures of bone microarchitecture in mouse bones. Current Developments in Nutrition. 3(Suppl_1). Abstract No. P01-032-19. https://doi.org/10.1093/cdn/nzz028.P01-032-19.

Nutritional modulation of immune function: analysis of evidence, mechanisms, and clinical relevance - (Review Article)
Wu, D., Lewis, E.D., Pae, M., Meydani, S.N. 2019. Nutritional modulation of immune function: analysis of evidence, mechanisms, and clinical relevance. Frontiers in Immunology. 9:3160. https://doi.org/10.3389/fimmu.2018.03160.

Naringenin modifies the development of lineage-specific effector CD4+ T cells - (Peer Reviewed Journal)
Wang, J., Xinli, N., Wu, C., Wu, D. 2018. Naringenin modifies the development of lineage-specific effector CD4+ T cells. Frontiers in Immunology. 9:2267. https://doi.org/10.3389/fimmu.2018.02267.

Hidden hunger: solutions for America's aging populations - (Review Article)
Eggersdorfer, M., Akobundu, U., Bailey, R.L., Shlisky Baxter, J., Beaudreault, A.R., Bergeron, G., Blancato, R.B., Blumberg, J.B., Bourassa, M.W., Gomes, F., Jensen, G., Johnson, M., Mackay, D., Marshall, K., Meydani, S.N., Tucker, K.L. 2018. Hidden hunger: solutions for America's aging populations. Nutrients. 10(9):1210. https://doi.org/10.3390/nu10091210.