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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » Research » Research Project #435838

Research Project: Characterization of the Evolution of Influenza A Viruses (IAV) in Swine

Location: Virus and Prion Research

Project Number: 5030-32000-120-23-A
Project Type: Cooperative Agreement

Start Date: Oct 15, 2018
End Date: Oct 14, 2023

Objective:
Visualize and track relevant genetic markers of hemagglutinin (HA) evolution and triage the sequence data for strains to antigenically characterize further. Use antibody landscapes to visualize ferret and swine immunity to swine influenza virus variants and to characterize and compare immune responses.

Approach:
Expand North American risk pipeline to South America, Europe, and Asia by establishing a second virus characterization hub with Cooperator in the U.K.Antigenic cartography will be used for quantification and visualization of antigenic data generated by hemagglutination inhibition (HI) assays, and HI assays will be used to predict population immunity to influenza A viruses (IAV). Monovalent reference swine antisera and ferret antisera that were generated against swine and human seasonal IAV and select IAV antigens will be used in HI assays. The antigenic distance between swine and human seasonal IAV will then be used to give a relative risk rank of swine IAV transmission and outbreaks in the human population.