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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Ruminant Diseases and Immunology Research » Research » Research Project #435672

Research Project: Cell Based Therapeutic Approach for Immunomodulation of Inflammatory Response for a Better Outcome in Dairy Animals with Mastitis

Location: Ruminant Diseases and Immunology Research

Project Number: 5030-32000-115-01-R
Project Type: Reimbursable Cooperative Agreement

Start Date: Oct 1, 2018
End Date: Sep 30, 2019

Objective:
We plan to test whether populating the mammary gland with an enriched population of mesenchymal stromal cells (MSCs) will promote the healing of existing infections and increase resistance to new infections in dairy animals with mastitis.

Approach:
Prior to the initiation of a large scale clinical trial in cows, we will examine the potential therapeutic effect of MSCs in tissue culture and mouse models. Aim 1: Isolation, expansion and characterization of mouse and bovine MSCs Aim 2: Functional characterization of the immunomodulatory effect of MSCs on mammary epithelial cells in tissue culture conditions Aim 3: Evaluation of the modulation of mammary inflammation by MSCs