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ARS Home » Pacific West Area » Albany, California » Western Regional Research Center » Healthy Processed Foods Research » Research » Research Project #435135

Research Project: Programmed Assembly of Cell Based Carriers for Improved Functionality of Bioactives in the Gut

Location: Healthy Processed Foods Research

Project Number: 2030-41440-007-07-R
Project Type: Reimbursable Cooperative Agreement

Start Date: Feb 1, 2018
End Date: Jan 31, 2019

Objective:
Develop natural bioactive carriers from yeast and algal cells that resist gastric and intestinal digestion but are degraded by gut bacteria and deliver encapsulated bioactive compounds to the colon. Correlate circulating and tissue inflammation with changes in the gut microbiota by encapsulated bioactives in a mouse model.

Approach:
Experimental approach will focus on influencing the cell wall permeability of the selected strains of yeast and algal cells to achieve optimal encapsulation efficiency while restricting the release of bioactives in gastric and small intestinal environment. Mouse model systems will evaluate the impact of the proposed delivery approach in both treating the fat induced inflammation as well as preventing the high-fat diet induced inflammation. In addition, synergistic interactions between the selected bioactive compounds using the proposed bio-encapsulation formulation will also be evaluated using a mouse model system. For evaluating synergistic interactions, both the model bioactive compounds will be simultaneously delivered using the optimized bio-encapsulation approaches.