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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » Research » Research Project #434490

Research Project: Comparative Genomic Assessment of the Evolution and Zoonotic Potential of MRSA ST5 Strains Isolated from Humans Living in US Swine Producing Regions

Location: Virus and Prion Research

Project Number: 5030-32000-119-12-R
Project Type: Reimbursable Cooperative Agreement

Start Date: Aug 1, 2018
End Date: Aug 1, 2019

Objective:
Determine the antimicrobial resistance (AMR) determinates and genomic elements that could increase the capacity of methicillin-resistant Staphylococcus aureus (MRSA) isolates to transmit, colonize, and/or cause disease in humans.

Approach:
Obtain draft genome sequence data of MRSA ST5 strains isolated from humans living in swine producing regions within the United States and/or working with swine. Use the data to perform single nucleotide polymorphism (SNP) typing to compare the population structure and genetic relatedness of ST5 strains isolated from humans living in swine producing regions to swine associated and clinical MRSA ST5 isolates. Screen the draft genome sequence data for antimicrobial resistance determinates and genomic elements that could increase the capacity of MRSA isolates to transmit, colonize, and/or cause disease in humans.