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ARS Home » Midwest Area » Lexington, Kentucky » Forage-animal Production Research » Research » Research Project #433380

Research Project: Optimizing the Biology of the Animal-Plant Interface for Improved Sustainability of Forage-Based Animal Enterprises

Location: Forage-animal Production Research

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Effects of bromocriptine on glucose and insulin dynamics in normal and insulin dysregulated horses Reprint Icon - (Peer Reviewed Journal)
Loos, C.M., Urschel, K.L., Vanzant, E.S., Oberhaus, E.L., Bohannan, A.D., Klotz, J.L., Mcleod, K.M. 2022. Effects of bromocriptine on glucose and insulin dynamics in normal and insulin dysregulated horses. Frontiers in Veterinary Science. 9. Article 889888. https://doi.org/10.3389/fvets.2022.889888.

Isoflavone containing legumes mitigate ergot alkaloid-induced vasoconstriction in goats (Capra hircus) Reprint Icon - (Peer Reviewed Journal)
Harlow, B.E., Flythe, M.D., Goodman, J.P., Ji, H., Aiken, G.E. 2022. Isoflavone containing legumes mitigate ergot alkaloid-induced vasoconstriction in goats (Capra hircus). Animals. 12(6). Article 750. https://doi.org/10.3390/ani12060750.

Global impact of ergot alkaloids Reprint Icon - (Review Article)
Klotz, J.L. 2022. Global impact of ergot alkaloids. Toxins. 14(3). Article 186. https://doi.org/10.3390/toxins14030186.

Influence of prolonged serotonin and ergovaline pre-exposure on vasoconstriction ex vivo Reprint Icon - (Peer Reviewed Journal)
Valente, E.E., Harmon, D.L., Klotz, J.L. 2021. Influence of prolonged serotonin and ergovaline pre-exposure on vasoconstriction ex vivo. Toxins. 14(1):9. https://doi.org/10.3390/toxins14010009.

Spent craft brewer’s yeast reduces production of methane and ammonia by bovine rumen microbes Reprint Icon - (Peer Reviewed Journal)
Bryant, R.W., Burns, E.E., Feidler-Cree, C., Carlton, D., Flythe, M.D., Martin, L.J. 2021. Spent craft brewer’s yeast reduces production of methane and ammonia by bovine rumen microbes. Frontiers in Animal Science. 2. Article 720646. https://doi.org/10.3389/fanim.2021.720646.

Effects of overseeding red clover in endophyte-infected tall fescue pastures on steer physiology and performance Reprint Icon - (Peer Reviewed Journal)
Harlow, B.E., Flythe, M.D., Hamilton, T.A., Ji, H., Schrick, F., Aiken, G.E. 2021. Effects of overseeding red clover in endophyte-infected tall fescue pastures on steer physiology and performance. Applied Animal Science. 37(6):748-757. https://doi.org/10.15232/aas.2021-02152.

Effect of biochanin A on the rumen microbial community of Holstein steers consuming a high fiber diet and subjected to a subacute acidosis challenge Reprint Icon - (Peer Reviewed Journal)
Harlow, B.E., Flythe, M.D., Klotz, J.L., Harmon, D.L., Aiken, G.E. 2021. Effect of biochanin A on the rumen microbial community of Holstein steers consuming a high fiber diet and subjected to a subacute acidosis challenge. PLoS ONE. 16(7). Article e0253754. https://doi.org/10.1371/journal.pone.0253754.

Residual effects of abomasal 5-hydroxytryptophan administration on serotonin metabolism in cattle Reprint Icon - (Peer Reviewed Journal)
Valente, E.E., Demasceno, M.L., Klotz, J.L., Harmon, D.L. 2021. Residual effects of abomasal 5-hydroxytryptophan administration on serotonin metabolism in cattle. Domestic Animal Endocrinology. 76. Article 106627. https://doi.org/10.1016/j.domaniend.2021.106627.

Effects of tall fescue endophyte type and dopamine receptor D2 genotype on cow-calf performance during late gestation and early lactation Reprint Icon - (Peer Reviewed Journal)
Wilbanks, S.A., Justice, S., West, T., Klotz, J.L., Andrae, J.G., Duckett, S.K. 2021. Effects of tall fescue endophyte type and dopamine receptor D2 genotype on cow-calf performance during late gestation and early lactation. Toxins. 13(3). Article 195. https://doi.org/10.3390/toxins13030195.

Clover makes fescue better for goats - (Trade Journal)
Flythe, M.D. 2021. Clover makes fescue better for goats. Trade Journal Publication. 33(1):18-19.

Rumen and serum metabolomes in response to endophyte-infected tall fescue seed and isoflavone supplementation in beef steers Reprint Icon - (Peer Reviewed Journal)
Seay, T.B., Melchior, E.A., Clemmons, B.A., Cordero, J.F., Bates, G.E., Flythe, M.D., Klotz, J.L., Ji, H., Goodman, J.P., McLean, K.J., Myer, P.R. 2020. Rumen and serum metabolomes in response to endophyte-infected tall fescue seed and isoflavone supplementation in beef steers. Toxins. 12(12). Article 744. https://doi.org/10.3390/toxins12120744.

Ergot alkaloid exposure during gestation: I. Impacts on ewe milk production, lamb birth weight and pre-weaning growth rate Reprint Icon - (Peer Reviewed Journal)
Britt, J.L., Greene, M.A., Wilbanks, S.A., Bertrand, J., Klotz, J.L., Bridges, Jr., W.C., Aiken, G.E., Andrae, J.G., Duckett, S.K. 2020. Ergot alkaloid exposure during gestation: I. Impacts on ewe milk production, lamb birth weight and pre-weaning growth rate. Animals. 10(12). Article 2291. https://doi.org/10.3390/ani10122291.

Ergot alkaloids reduce circulating serotonin in the bovine Reprint Icon - (Peer Reviewed Journal)
Valente, E.E., Klotz, J.L., Ahn, G., McLeod, K.R., Herzing, H.M., King, M., Harmon, D.L. 2020. Ergot alkaloids reduce circulating serotonin in the bovine. Journal of Animal Science. 98(12):skaa362. https://doi.org/10.1093/jas/skaa362.

Evaluation of oral citrulline administration as a mitigation strategy for fescue toxicosis in sheep Reprint Icon - (Peer Reviewed Journal)
Greene, M.A., Klotz, J.L., Goodman, J.P., May, J.B., Harlow, B.E., Baldwin, W., Strickland, J.R., Britt, J.L., Schrick, F.N., Duckett, S.K. 2020. Evaluation of oral citrulline administration as a mitigation strategy for fescue toxicosis in sheep. Translational Animal Science. 4(4):txaa197. https://doi.org/10.1093/tas/txaa197.

Feeding tall fescue seed during mid and late gestation influences subsequent postnatal growth, puberty, and carcass quality of offspring Reprint Icon - (Peer Reviewed Journal)
Greene, M.A., Britt, J.L., Bertrand, J., Klotz, J.L., Bridges, Jr., W.C., Andrae, J.G., Duckett, S.K. 2020. Feeding tall fescue seed during mid and late gestation influences subsequent postnatal growth, puberty, and carcass quality of offspring. Animals. 10(10). Article 1859. https://doi.org/10.3390/ani10101859.

Pattern of postruminal administration of L-tryptophan affects blood serotonin in cattle Reprint Icon - (Peer Reviewed Journal)
Valente, E.E., Klotz, J.L., Ahn, G., Harmon, D.L. 2021. Pattern of postruminal administration of L-tryptophan affects blood serotonin in cattle. Domestic Animal Endocrinology. 74. Article 106574. https://doi.org/10.1016/j.domaniend.2020.106574.

5-Hydroxytryptophan strongly stimulates serotoninsynthesis in Holstein steers Reprint Icon - (Peer Reviewed Journal)
Valente, E.E., Klotz, J.L., Harmon, D.L. 2020. 5-Hydroxytryptophan strongly stimulates serotoninsynthesis in Holstein steers. Domestic Animal Endocrinology. 74. Article 106560. https://doi.org/10.1016/j.domaniend.2020.106560.

A moderate transition of beef heifers to a 90% concentrate diet as a model for subacute ruminal acidosis induced alterations in feeding behavior, rumen environment, reticulorumen motility, and blood acid-base status Reprint Icon - (Peer Reviewed Journal)
Egert-McLean, A.M., Sama, M.P., Klotz, J.L., McLeod, K.R., Kristensen, N.B., Harmon, D.L. 2020. A moderate transition of beef heifers to a 90% concentrate diet as a model for subacute ruminal acidosis induced alterations in feeding behavior, rumen environment, reticulorumen motility, and blood acid-base status. Canadian Journal of Animal Science. 101(1):85-95. https://doi.org/10.1139/cjas-2019-0218.

Isoflavone supplementation, via red clover hay, alters the rumen microbial community and promotes weight gain of steers grazing mixed grass pastures Reprint Icon - (Peer Reviewed Journal)
Harlow, B.E., Flythe, M.D., Kagan, I., Goodman, J.P., Klotz, J.L., Aiken, G.E. 2020. Isoflavone supplementation, via red clover hay, alters the rumen microbial community and promotes weight gain of steers grazing mixed grass pastures. PLoS One. 15(3): e0229200. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229200.

Ruminal motility, reticulo-ruminal fill and eating patterns in steers exposed to ergovaline Reprint Icon - (Peer Reviewed Journal)
Ahn, G., Riccioni, K., Avila, S., Klotz, J.L., Harmon, D.L. 2019. Ruminal motility, reticulo-ruminal fill and eating patterns in steers exposed to ergovaline. Journal of Animal Science. 98(1):1-11. https://doi.org/10.1093/jas/skz374.

Effects of hops (Humulus lupulus L.) beta-acids on short chain fatty acid production from complex carbohydrates by rumen microbiota Reprint Icon - (Peer Reviewed Journal)
Flythe, M.D., Harlow, B.E. 2019. Effects of hops (Humulus lupulus L.) beta-acids on short chain fatty acid production from complex carbohydrates by rumen microbiota. Advances in Microbiology. 9(12):983-992. https://doi.org/10.4236/aim.2019.912063.

Red clover dosed in loose mineral mitigates vasoconstriction in steers challenged with E+ tall fescue seed - (Abstract Only)
Harlow, B.E., Johns, J.T., Flythe, M.D. 2020. Red clover dosed in loose mineral mitigates vasoconstriction in steers challenged with E+ tall fescue seed. American Forage and Grassland Conference Proceedings. 1:12.

Automated system for characterizing short-term feeding behavior and real-time forestomach motility in cattle Reprint Icon - (Peer Reviewed Journal)
Egert-Mclean, A.M., Sama, M.P., Klotz, J.L., McLeod, K.R., Kristensen, N.B., Harmon, D.L. 2019. Automated system for characterizing short-term feeding behavior and real-time forestomach motility in cattle. Computers and Electronics in Agriculture. 167:105037. https://doi.org/10.1016/j.compag.2019.105037.

How ruminant antibiotic growth promoters work and functional feeds as alternatives - (Proceedings)
Flythe, M.D., Harlow, B.E. 2019. How ruminant antibiotic growth promoters work and functional feeds as alternatives. Meeting Proceedings. 1:25.

Current research in red clover isoflavones as functional feed in beef cattle production - (Proceedings)
Harlow, B.E., Flythe, M.D. 2019. Current research in red clover isoflavones as functional feed in beef cattle production. Meeting Proceedings. 1:20.

Effects of oral citrulline:malate administration to ewes fed ergot alkaloids during late gestation on neonatal serum amino acids and growth - (Abstract Only)

Ergocornine Reprint Icon - (Review Article)
Klotz, J.L. 2019. Ergocornine. Review Article. https://doi.org/10.1016/B978-0-12-801238-3.98305-3.

Determination of serotonergic receptor profiles in equine palmar artery and vein and uterine artery - (Abstract Only)

Ergot alkaloid exposure during gestation alters: III. Fetal growth, muscle fiber development, and miRNA transcriptome Reprint Icon - (Peer Reviewed Journal)
Greene, M.A., Britt, J.L., Powell, R., Feltus, F.A., Bridges, Jr., W.C., Bruce, T., Klotz, J.L., Miller, M.F., Duckett, S.K. 2019. Ergot alkaloid exposure during gestation alters: III. Fetal growth, muscle fiber development, and miRNA transcriptome. Journal of Animal Science. https://doi.org/10.1093/jas/skz153.

Determination of serotonergic receptor profiles in equine palmar artery and vein and uterine artery - (Abstract Only)

Ergot alkaloid exposure during gestation alters: II. Uterine and umbilical artery vasoactivity Reprint Icon - (Peer Reviewed Journal)
Klotz, J.L., Britt, J.L., Miller, M.F., Snider, M.A., Aiken, G.E., Long, N.M., Pratt, S.L., Andrae, J.G., Duckett, S.K. 2019. Ergot alkaloid exposure during gestation alters: II. Uterine and umbilical artery vasoactivity. Journal of Animal Science. 97(4):1891-1902.

Ergot alkaloid exposure during gestation alters: I. Maternal characteristics and placental development Reprint Icon - (Peer Reviewed Journal)
Britt, J.L., Greene, M.A., Bridges, Jr., W.C., Klotz, J.L., Aiken, G.E., Andrae, J.G., Pratt, S.L., Long, N.M., Schrick, F., Strickland, J.R., Wilbanks, S.A., Miller, Jr., M.F., Koch, B.M., Duckett, S.K. 2019. Ergot alkaloid exposure during gestation alters: I. Maternal characteristics and placental development. Journal of Animal Science. 97(4):1874-1890. https://doi.org/10.1093/jas/skz068.

Effects of endophyte-infected tall fescue seed and red clover isoflavones on rumen microbial populations and physiological parameters of beef cattle Reprint Icon - (Peer Reviewed Journal)
Melchior, E.A., Smith, J.K., Schneider, L.G., Mulliniks, J.T., Bates, G.E., Flythe, M.D., Klotz, J.L., Ji, H., Goodman, J.P., Lee, A.R., Caldwell, J.M., Myer, P.R. 2018. Effects of endophyte-infected tall fescue seed and red clover isoflavones on rumen microbial populations and physiological parameters of beef cattle. Translational Animal Science. 3:316-328. https://doi.org/10.1093/tas/txy147.

Environmental pollutant-mediated disruption of gut microbial metabolism of the prebiotic inulin - (Peer Reviewed Journal)

Effects of red clover isoflavones on tall fescue seed fermentation and microbial populations in vitro Reprint Icon - (Peer Reviewed Journal)
Melchior, E.A., Smith, J.K., Schneider, L.G., Mulliniks, J.T., Bates, G.E., McFarlane, Z.D., Flythe, M.D., Klotz, J.L., Goodman, J.P., Ji, H., Meyer, P.R. 2018. Effects of red clover isoflavones on tall fescue seed fermentation and microbial populations in vitro. Animal Feed Science And Technology. 13(10): e0201866. https://doi.org/10.1371/journal.pone.0201866.

Interaction of ergovaline with serotonin receptor 5-HT2A in bovine ruminal and mesenteric vasculature Reprint Icon - (Peer Reviewed Journal)
Trotta, R.J., Harmon, D.L., Klotz, J.L. 2018. Interaction of ergovaline with serotonin receptor 5-HT2A in bovine ruminal and mesenteric vasculature. Journal of Animal Science. 96:4912-4922. https://doi.org/10.1093/jas/sky346.

Effects of source and level of dietary energy supplementation on in vitro digestibility and methane production from tall fescue-based diets Reprint Icon - (Peer Reviewed Journal)
Trotta, R.J., Klotz, J.L., Harmon, D.L. 2018. Effects of source and level of dietary energy supplementation on in vitro digestibility and methane production from tall fescue-based diets. Animal Feed Science And Technology. 242:41-47. https://doi.org/10.1016/j.anifeedsci.2018.05.010.

Effects of different levels of lespedeza and supplementation with monensin, coconut oil, or soybean oil on ruminal methane emission by mature Boer goat wethers after different lengths of feeding - (Peer Reviewed Journal)
Puchala, R., LeShure, S., Gipson, T.A., Tesfai, K., Flythe, M.D., Goetsch, A.L. 2018. Effects of different levels of lespedeza and supplementation with monensin, coconut oil, or soybean oil on ruminal methane emission by mature Boer goat wethers after different lengths of feeding. Journal of Applied Animal Research. 46(1): 1127-1136.

Effects of grazing different ergovaline concentrations on vasoactivity of bovine lateral saphenous vein Reprint Icon - (Peer Reviewed Journal)
Klotz, J.L., Aiken, G.E., Egert-McLean, A.M., Schrick, F., Chattopadhyay, N., Harmon, D.L. 2018. Effects of grazing different ergovaline concentrations on vasoactivity of bovine lateral saphenous vein. Journal of Animal Science. 6:3022–3030. doi: 10.1093/jas/sky163.

Managements for mitigating fescue toxicosis - (Proceedings)
Flythe, M.D. 2018. Managements for mitigating fescue toxicosis. American Forage and Grassland Conference Proceedings. http://www.afgc.org/proceedings/2018/.

Pharmacologic assessment of bovine ruminal and mesenteric vascular serotonin receptor populations - (Peer Reviewed Journal)
Snider, M.A., Harmon, D.L., Matthews, J.C., Klotz, J.L. 2018. Pharmacologic assessment of bovine ruminal and mesenteric vascular serotonin receptor populations. Journal of Animal Science. 96(4):1570-1578.

Contractile response of bovine lateral saphenous vein to ergotamine tartrate exposed to different concentrations of molecularly imprinted polymers Reprint Icon - (Peer Reviewed Journal)
Kudupoje, M.B., Klotz, J.L., Yiannikouris, A., Dawson, K.A., McLeod, K.R., Vanzant, E.S. 2018. Contractile response of bovine lateral saphenous vein to ergotamine tartrate exposed to different concentrations of molecularly imprinted polymers. Toxins. 10(2):58. https://doi:10.3390/toxins10020058.

Inhibition of growth and ammonia production of ruminal hyper ammonia-producing bacteria by Chinook or Galena hops after long-term storage - (Peer Reviewed Journal)
Flythe, M.D., Harlow, B.E., Aiken, G.E., Gellin, G.L., Kagan, I., Pappas, J. 2017. Inhibition of growth and ammonia production of ruminal hyper ammonia-producing bacteria by Chinook or Galena hops after long-term storage. Fermentation. 3(68)1-9.

Biochanin A improves fiber fermentation by cellulolytic bacteria - (Peer Reviewed Journal)
Harlow, B.E., Aiken, G.E., Flythe, M.D. 2017. Biochanin A improves fiber fermentation by cellulolytic bacteria. Journal of Applied Microbiology. 124(1):58-66.