Location: Animal Disease Research
Project Number: 2090-32000-040-005-A
Project Type: Cooperative Agreement
Start Date: Aug 1, 2017
End Date: Jul 31, 2022
The objective of this collaborative proposal is to understand Babesia genotypic and phenotypic diversity among isolates, tick transmission efficiency, and identify antigens to develop vaccines to prevent pathogen transmission and/or disease manifestation in the mammalian host.
Protozoan parasites transmitted by ticks remain the major concern and challenge for the livestock industries. Due to the lack of control strategies, tick-borne pathogens cause significant economic losses for cattle industry as well as for the horse industry. Parasites are inoculated into naïve animals via tick saliva and cause acute disease and, in some cases, animals succumb with high parasitemia. Animals that survive acute disease are persistently infected and are reservoirs for tick transmission. Understanding infection prevalence/incidence of mammalian hosts and infection of ticks is critical for the development of efficient strategies to control pathogen spread.