Project Number: 6054-43440-046-13-I
Project Type: Interagency Reimbursable Agreement
Start Date: Apr 15, 2017
End Date: Apr 14, 2020
Improving diagnosis of true peanut and tree nut allergy and cross-reactivity.
We propose to identify the IgE and IgG4 biding sites for known peanut and tree nut allergens with serum from approximately 250 clinically well-characterized, nut allergic individuals and 100 non-allergic individuals from different locations around the US. Following professional statistical analysis, the clinically important versus unimportant IgE and IgG4 binding will be identified and used to improve diagnosis of nut allergy and clinically symptomatic cross-reactivity among nuts.