Research Project: Intervention Strategies to Prevent and Control Enteric Diseases of Poultry

Location: Endemic Poultry Viral Diseases Research

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Heterologous prime-boost regimens with Ad5 and NDV vectors elicit stronger immune responses to Ebola virus than homologous regimens in mice - (Peer Reviewed Journal)
Zhao, W., Zhang, P., Bai, S., Lv, M., Wang, J., Chen, W., Yu, Q., Wu, J. 2021. Heterologous prime-boost regimens with Ad5 and NDV vectors elicit stronger immune responses to Ebola virus than homologous regimens in mice. Archives of Virology. https://doi.org/10.1007/s00705-021-05234-4.

Pathogenic evaluation of a turkey coronavirus isolate (TCoV NC1743) in turkey poults for establishing a TCoV disease model - (Peer Reviewed Journal)
Kang, K., Day, J.M., Eldemery, F., Yu, Q. 2021. Pathogenic evaluation of a turkey coronavirus isolate (TCoV NC1743) in turkey poults for establishing a TCoV disease model. Veterinary Microbiology. 259:109155. https://doi.org/10.1016/j.vetmic.2021.109155.

Enhanced protection by recombinant newcastle disease virus expressing infectious bronchitis virus spike ectodomain and chicken granulocyte-macrophage colony-stimulating factor - (Peer Reviewed Journal)
Khalid, Z., He, L., Yu, Q., Breedlove, C., Joiner, K., Toro, H. 2021. Enhanced protection by recombinant newcastle disease virus expressing infectious bronchitis virus spike ectodomain and chicken granulocyte-macrophage colony-stimulating factor. Avian Diseases. 65(3):364–372. https://doi.org/10.1637/aviandiseases-D-21-00032.

Newcastle disease virus recombinant expressing two foreign genes from the optimal insertion sites for use as a multivalent vaccine vector. - (Abstract Only)

The recombinant Newcastle disease virus Anhinga strain expressing human TRAIL exhibit antitumor effects on a glioma nude mice model - (Peer Reviewed Journal)
He, J., An, Y., Qi, J., Cui, L., Yang, K., Liu, M., Qu, B., Yan, S., Yin, J., Jing, X., Dong, H., Yu, Q., Li, D., Wu, Y. 2020. The recombinant Newcastle disease virus Anhinga strain expressing human TRAIL exhibit antitumor effects on a glioma nude mice model. Journal of Medical Virology. 93(6):3890-3898. https://doi.org/10.1002/jmv.26419.

Attenuation of NDV LaSota strain by codon pair deoptimization of the HN and F genes is not sufficient for in ovo vaccination - (Abstract Only)

Expression of two foreign genes by a Newcastle disease virus vector from the optimal insertion sites through a combination of the ITU and IRES-dependent expression approaches - (Peer Reviewed Journal)
He, L., Zhang, Z., Yu, Q. 2020. Expression of two foreign genes by a Newcastle disease virus vector from the optimal insertion sites through a combination of the ITU and IRES-dependent expression approaches. Frontiers in Microbiology. 11:769. https://doi.org/10.3389/fmicb.2020.00769.

Optimization of oncolytic effect of Newcastle disease virus Clone30 by selecting sensitive tumor host and constructing more oncolytic viruses - (Peer Reviewed Journal)
Liu, T., Zhang, Y., Cao, Y., Jiang, S., Sun, R., Yin, J., Gao, Z., Ren, G., Wang, Z., Yu, Q., Sui, G., Sun, X., Sun, W., Xiao, W., Li, D. 2020. Optimization of oncolytic effect of Newcastle disease virus Clone30 by selecting sensitive tumor host and constructing more oncolytic viruses. Gene Therapy. https://doi.org/10.1038/s41434-020-0145-9.

Expression of two foreign genes from the optimal insertion sites of Newcastle disease virus vector for use as a multivalent vaccine and gene therapy vector - (Abstract Only)
He, L., Zhang, Z., Yu, Q. 2020. Expression of two foreign genes from the optimal insertion sites of Newcastle disease virus vector for use as a multivalent vaccine and gene therapy vector. Meeting Abstract. https://viruses2020.sciforum.net/conferences_files/265/customs/8e7a8d27a5bbc4414b3bd49b0dfe4dd2.pdf.

Codon pair deoptimization of the HN and F of NDV LaSota strain does not significantly attenuate the virus for in ovo vaccination - (Abstract Only)
Eldemery, F., Ou, C., Kim, T.N., Spatz, S.J., Dunn, J.R., Silva, R.F., Yu, Q. 2020. Codon pair deoptimization of the HN and F of NDV LaSota strain does not significantly attenuate the virus for in ovo vaccination. Proceedings of Southern Conference on Avian Diseases. In: ABSTRACTS of 2020 International Poultry Scientific Forum, p73. Atlanta, GA, 28-30 January 2020.

Limited protection conferred by recombinant Newcastle disease virus expressing infectious bronchitis spike protein - (Peer Reviewed Journal)
Zegpi, R.A., He, L., Yu, Q., Joiner, K.S., Van Santen, V.C., Toro, H. 2020. Limited protection conferred by recombinant Newcastle disease virus expressing infectious bronchitis spike protein. Avian Diseases. 64(1):53-59. https://doi.org/10.1637/0005-2086-64.1.53.

Genetic stability of a Newcastle disease virus vectored infectious laryngotracheitis virus vaccine after serial passages in chicken embryos - (Peer Reviewed Journal)
Yu, Q., Li, Y., Dimitrov, K., Afonso, C.L., Spatz, S.J., Zsak, L. 2020. Genetic stability of a Newcastle disease virus vectored infectious laryngotracheitis virus vaccine after serial passages in chicken embryos. Vaccine. 38(4):925-932. https://doi.org/10.1016/j.vaccine.2019.10.074.

Generation of recombinant Newcastle disease virus expressing the S1 protein of turkey enteric coronavirus for use as a bivalent vaccine - (Abstract Only)
Li, Y., Day, J.M., Yu, Q. 2018. Generation of recombinant Newcastle disease virus expressing the S1 protein of turkey enteric coronavirus for use as a bivalent vaccine [abstract]. 12th Vaccine Congress in Budapest, Hungry, September 16-19, 2018. Paper No. 2.27.

Generation of a recombinant Newcastle disease virus expressing two foreign genes for use as a multivalent vaccine and gene therapy vector - (Peer Reviewed Journal)
Hu, H., Roth, J.P., Yu, Q. 2018. Generation of a recombinant Newcastle disease virus expressing two foreign genes for use as a multivalent vaccine and gene therapy vector. Vaccine. 36:4846-4850. https://doi.org/10.1016/j.vaccine.2018.06.055.

Maternally derived antibodies in commercial broiler chickens did not significantly interfere with protection of Newcastle disease virus vectored infectious laryngotracheitis vaccines - (Abstract Only)

A novel genotype VII Newcastle disease virus vaccine candidate generated by mutation in the L and F genes confers improved protection in chickens - (Peer Reviewed Journal)
Ji, Y., Liu, T., Du, Y., Cui, X., Yu, Q., Wang, Z., Li, Y., Zhu, Q. 2018. A novel genotype VII Newcastle disease virus vaccine candidate generated by mutation in the L and F genes confers improved protection in chickens. Veterinary Microbiology. 216:99-106. https://doi.org/10.1016/j.vetmic.2018.01.021.

Isolation and genomic characterization of a novel avian orthoreovirus in Korea, 2014 - (Peer Reviewed Journal)
Noh, J., Lee, D., Lim, T., Lee, J., Day, J.M., Song, C. 2018. Isolation and genomic characterization of a novel avian orthoreovirus in Korea, 2014. Archives of Virology. 163:1307-1316. https://doi.org/10.1007/s00705-017-3667-8.

Two single mutations in the fusion protein of Newcastle disease virus confer hemagglutinin-neuraminidase independent fusion promotion and attenuate the pathogenicity in chickens - (Peer Reviewed Journal)
Ji, Y., Liu, T., Liu, B., Yu, Q., Cui, X., Guo, F., Chang, H., Zhu, Q. 2017. Two single mutations in the fusion protein of Newcastle disease virus confer hemagglutinin-neuraminidase independent fusion promotion and attenuate the pathogenicity in chickens. Virology. 509:146-151. https://doi.org/10.1016/j.virol.2017.06.021.

Effects of insertion sites in a Newcastle disease virus vector on foreign gene expression through an internal ribosomal entry site - (Abstract Only)

Development of a Newcastle disease virus vector expressing a foreign gene through an internal ribosomal entry site provides direct proof for a sequential transcription mechanism - (Abstract Only)
Yu, Q., Zhang, Z., Zhao, W., Li, D., Yang, J., Zsak, L. 2017. Development of a Newcastle disease virus vector expressing a foreign gene through an internal ribosomal entry site provides direct proof for a sequential transcription mechanism [abstract]. The 17th International Congress of Virology, July 17-21, 2017, Singapore. p. 21.

Engineered newcastle disease virus expressing the F and G protein of AMPV-C confers protection against challenges in turkeys. - (Peer Reviewed Journal)
Hu, H., Roth, J., Zsak, L., Yu, Q. 2017. Engineered newcastle disease virus expressing the F and G protein of AMPV-C confers protection against challenges in turkeys. Scientific Reports. 7:4025. http://doi:10.1038/s41598-017-04267-7.

infections bronchitis virus S2 of 4/91 expressed from recombinant virus does not protect against ark-type challenge - (Peer Reviewed Journal)
Eldemery, F., Li, Y., Yu, Q., Van Santen, V., Toro, H. 2017. infectious bronchitis virus S2 of 4/91 expressed from recombinant virus does not protect against ark-type challenge. Acarology International Congress Proceedings. 61(3):397-401. https://doi.org/10.1637/11632-032017-ResNoteR.

Investigating the Use of an Enterotropic Newcastle Disease Virus as a Recombinant Vaccine Platform Targeting Poultry Enteric Viruses - (Abstract Only)

Recombinant Newcastle disease virus expressing human TRAIL as a potential candidate for hepatoma therapy - (Peer Reviewed Journal)
Wu, Y., He, J., Geng, J., An, Y., Ye, X., Yan, S., Yu, Q., Yin, J., Zhang, Z., Li, D. 2017. Recombinant Newcastle disease virus expressing human TRAIL as a potential candidate for hepatoma therapy. European Journal of Pharmacology. 802:85–92. doi:org/10.1016/j.ejphar.2017.02.042.