Location: Endemic Poultry Viral Diseases Research
2021 Annual Report
Accomplishments
1. Turkey coronavirus (TCoV) can cause a highly contagious enteric disease in turkeys with severe economic losses in the global turkey industry. To date, no commercial vaccines are available for control of the disease. Many factors could obstruct the TCoV vaccine development. Undoubtedly, the lack of a TCoV disease model for the evaluation of a vaccine protective efficacy is an important one. To establish a TCoV disease model, ARS researchers in Athens, Georgia, isolated a field strain (NC1743) of TCoV and evaluated its pathogenicity in specific-pathogen-free (SPF) turkey poults. The results showed that this TCoV strain was highly pathogenic and able to reproduce a typical enteric disease in day-old turkey poults with a standard minimal infectious dose. As the age increases, turkey poults became less sensitive to TCoV infection. The overall data suggest that young turkeys infected with the TCoV NC1743 strain could be used as a TCoV disease model to study the disease pathogenesis, and the minimal infectious dose of TCoV NC1743 could be used as a challenge virus to evaluate a vaccine protective efficacy.
Review Publications
Liu, T., Zhang, Y., Cao, Y., Jiang, S., Sun, R., Yin, J., Gao, Z., Ren, G., Wang, Z., Yu, Q., Sui, G., Sun, X., Sun, W., Xiao, W., Li, D. 2020. Optimization of oncolytic effect of Newcastle disease virus Clone30 by selecting sensitive tumor host and constructing more oncolytic viruses. Gene Therapy. https://doi.org/10.1038/s41434-020-0145-9.
He, J., An, Y., Qi, J., Cui, L., Yang, K., Liu, M., Qu, B., Yan, S., Yin, J., Jing, X., Dong, H., Yu, Q., Li, D., Wu, Y. 2020. The recombinant Newcastle disease virus Anhinga strain expressing human TRAIL exhibit antitumor effects on a glioma nude mice model. Journal of Medical Virology. 93(6):3890-3898. https://doi.org/10.1002/jmv.26419.
